Separating the effects of early and later life body mass index on liver diseases: A Mendelian randomization study - 30/04/24
Highlights |
• | The study assessed the independent impacts of childhood and adult BMI on NAFLD, cirrhosis, and HCC. |
• | The main finding is that the association between childhood BMI and risk of NAFLD may be mediated by adult BMI. |
• | The research will impact public health policies, healthcare practices, and family care strategies by emphasizing the importance of managing childhood obesity to prevent NAFLD. |
Abstract |
Background and aim |
The independent effects of childhood and adult body mass index (BMI) on non-alcoholic fatty liver disease (NAFLD), cirrhosis, and hepatocellular carcinoma (HCC) are lacking assessment. We aimed to separate the effects of childhood and adult BMI on NAFLD, cirrhosis, and HCC.
Methods |
Genetic variants associated with childhood and adult BMI were selected as instrumental variables. Two-sample univariable and multivariable MR estimated the total and direct effect of childhood and adult BMI on NAFLD, cirrhosis, and HCC.
Results |
Genetically predicted each 1-SD increased childhood BMI (OR = 1.30, 95 % CI = 1.12 to 1.51, P = 0.001) and adult BMI (OR = 1.57 95 % CI = 1.33 to 1.84, P = 5.49E-08) was associated with an increased risk of NAFLD. The association between childhood BMI (OR = 0.97, 95 % CI = 0.77 to 1.24, P = 0.825) and NAFLD did not remain significant after adjusting for adult BMI (OR = 1.64, 95 % CI = 1.23 to 2.20, P = 0.001). The direct effects of childhood and adult BMI on cirrhosis and HCC were insignificant after considering their relationship.
Conclusion |
Maintaining a normal BMI in adulthood significantly reduces the adverse effect of a higher childhood BMI on NAFLD. Further investigation is required to clarify the presence of this effect in cirrhosis and HCC.
Le texte complet de cet article est disponible en PDF.Keywords : Mendelian randomization, Body mass index, Non-alcoholic fatty liver disease, Cirrhosis, Hepatocellular carcinoma
Abbreviations : NAFLD, HCC, BMI, MR, GWAS, SNPs, EGG, MR-RAPS
Plan
Vol 48 - N° 6
Article 102352- juin 2024 Retour au numéro
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