919 granules improve postpartum depression through the regulation of abnormal peripheral blood IL-1β - 27/04/24
Abstract |
Postpartum depression (PPD) has a significant impact on the physical and mental health of mothers, potentially leading to symptoms such as low mood, fatigue, and decreased appetite. It may also affect the healthy growth of the infant. The onset of PPD is closely related to abnormalities in inflammation and the immune system. PPD patients exhibit abnormalities in the proportion of peripheral blood immune cells, along with an increase in pro-inflammatory cytokines. Excessive pro-inflammatory cytokines in peripheral blood can disrupt the blood-brain barrier (BBB) by activating astrocytes and reducing transendothelial electrical resistance (TEER), allowing peripheral immune cells or cytokines to enter the brain and trigger inflammation, ultimately leading to the onset of depression. In addition, PPD lacks safe and effective treatment medications. In this study, we collected peripheral blood from both healthy postpartum women and those with PPD, conducted single cell RNA sequencing (scRNA-seq), and used an in-house analytical tool scSTAR to reveal that PPD patients exhibit elevated proportions of peripheral blood cDC2 and Proliferation B cells, which are significantly correlated with IL-1β. Additionally, animal experiments were designed to validate that 919 granules can improve PPD by modulating the levels of peripheral blood IL-1β, providing a potential therapeutic mechanism for PPD treatment.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Postpartum depression patients exhibit an increased proporation of peripheral blood cDC2 and proliferation B cells. |
• | cDC2 can interact with proliferation B cells, and leading to an increase in IL-1beta secretion. |
• | 919 granules can improve postpartum depression by regulating the levels of peripheral blood IL-1β. |
Keywords : Postpartum depression, Single cell RNA sequencing, CDC2, Proliferation B cells, IL-1β, 919 granules
Plan
Vol 174
Article 116623- mai 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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