Tumor extrachromosomal DNA: Biogenesis and recent advances in the field - 27/04/24
Abstract |
Extrachromosomal DNA (ecDNA) is a self-replicating circular DNA originating from the chromosomal genome and exists outside the chromosome. It contains specific gene sequences and non-coding regions that regulate transcription. Recent studies have demonstrated that ecDNA is present in various malignant tumors. Malignant tumor development and poor prognosis may depend on ecDNA's distinctive ring structure, which assists in amplifying oncogenes. During cell division, an uneven distribution of ecDNA significantly enhances tumor cells' heterogeneity, allowing tumor cells to adapt to changes in the tumor microenvironment and making them more resistant to treatments. The application of ecDNA as a cancer biomarker and therapeutic target holds great potential. This article examines the latest advancements in this area and discusses the potential clinical applications of ecDNA.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Proposed and explained all the possible models for ecDNA biogenesis. |
• | Described the signaling pathways that involved in the regulation of ecDNA biogenesis. |
• | Described the mechanism of ecDNA supporting tumor progression. |
• | The prospect of ecDNA application for cancer therapy was explained. |
Abbreviations : DMs, EccDNA, SpcDNA, T-circles, EcDNA, BFB Cycle, HSR, MN, SOCS 1, APOBEC3, MHC, MTX, MSH3, DNA-PKi, DSB, DNA-PKCS, NRAS, ICD, FGFR2, MARS, EIFs, ALEMs
Keywords : ecDNA,tumor heterogeneity,drug resistance,biomarkers,genetics
Plan
Vol 174
Article 116588- mai 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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