Co-administration of “L-Lysine, Vitamin C, and Zinc” increased the antioxidant activity, decreased insulin resistance, and improved lipid profile in streptozotocin-induced diabetic rats - 27/04/24
Abstract |
Purpose |
We previously showed the beneficial effect of L-Lysine (Lys), a chemical chaperone, on reducing diabetic complications in diabetic rats and type 2 diabetic patients. Herein, we evaluated the effect of Lys co-administration with Vitamin C and Zinc (Lys+VC+Zn), in diabetic rats.
Methods |
The streptozotocin (50 mg/Kg) was injected into male adult Wistar rats to induce diabetes. Then, different groups of normal and diabetic rats were treated with Lys and Lys+VC+Zn for five months. So, there were 0.1 % Lys in the drinking water of both groups. The control groups received water alone. During the experiment, the body weight, and various parameters were determined in the blood, serum/plasma, and urine of the rats.
Results |
The determination of biochemical indexes confirmed diabetes induction and its complications in rats. Treatment with either Lys or Lys+VC+Zn resulted in reduced blood glucose and protein glycation (decreasing AGEs and HbA1c), increased insulin secretion, alleviated insulin resistance and HOMA-IR, improved lipid profile and HDL functionality (LCAT and PON1), enhanced antioxidant status (FRAP and AOPP), improved kidney function (decreased microalbuminuria, serum urea, and creatinine), and increased chaperone capacity (HSP70). Lys+VC+Zn showed better effects on these parameters than Lys alone.
Conclusions |
The results of this study indicated that co-administration of Lys, a chemical chaperone, with two antioxidants (VC and Zn) potentiates its antidiabetic effects and prevent diabetic complications in rat model of diabetes.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Lys+VC+Zn improved diabetic markers in rats more effective than Lys alone. |
• | Lys+VC+Zn reduced blood glucose and improved insulin resistance in diabetic rats. |
• | Lys+VC+Zn inhibited non-enzymatic protein glycation, AGEs and HbA1c formation. |
• | Lys+VC+Zn effectively mitigated diabetic nephropathy markers. |
• | Lys+VC+Zn improved lipid profile and anti-oxidative status in diabetic rats. |
Keywords : Diabetic Complications, Protein glycation, Insulin resistance, Kidney function, Antioxidant, HSP70
Plan
Vol 174
Article 116525- mai 2024 Retour au numéro
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