Mechanical stress induced mitochondrial dysfunction in cardiovascular diseases: Novel mechanisms and therapeutic targets - 27/04/24
Abstract |
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Others and our studies have shown that mechanical stresses (forces) including shear stress and cyclic stretch, occur in various pathological conditions, play significant roles in the development and progression of CVDs. Mitochondria regulate the physiological processes of cardiac and vascular cells mainly through adenosine triphosphate (ATP) production, calcium flux and redox control while promote cell death through electron transport complex (ETC) related cellular stress response. Mounting evidence reveal that mechanical stress-induced mitochondrial dysfunction plays a vital role in the pathogenesis of many CVDs including heart failure and atherosclerosis. This review summarized mitochondrial functions in cardiovascular system under physiological mechanical stress and mitochondrial dysfunction under pathological mechanical stress in CVDs (graphical abstract). The study of mitochondrial dysfunction under mechanical stress can further our understanding of the underlying mechanisms, identify potential therapeutic targets, and aid the development of novel treatments of CVDs.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Mitochondria regulate cellular metabolism, proliferation, differentiation, stress and death in cardiovascular system. |
• | Shear stress and cyclic stretch modulate mitochondrial functions/disfunctions in cardiovascular cells. |
• | Mechanical stress induced mitochondrial dysfunction reveals pathogenesis and therapeutic targets of HF and atherosclerosis. |
• | Current methods for evaluating mitochondrial functions/dysfunctions and further research directions are discussed. |
Keywords : Mechanical stress, Mitochondrial dysfunction, Cardiovascular diseases (CVDs), Energy metabolism, Reactive oxygen species (ROS), Redox control, Shear stress, Cyclic stretch, Cardiomyocyte, Endothelial cells (ECs), Vascular smooth muscle cells (VSMCs)
Plan
Vol 174
Article 116545- mai 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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