Therapeutic vulnerabilities in triple negative breast cancer: Stem-like traits explored within molecular classification - 27/04/24
Abstract |
Triple Negative Breast Cancer (TNBC) is the most aggressive type of breast cancer (BC). Despite advances in the clinical management of TNBC, recurrence-related mortality remains a challenge. The stem-like phenotype of TNBC plays a significant role in the persistence of minimal disease residue after therapy. Individuals exhibiting stem-like characteristics are particularly prone to inducing malignant relapse accompanied by strong resistance. Therefore, stem-like traits have been broadly proposed as therapeutic vulnerabilities to treat TNBC and reduce recurrence. However, heterogeneity within TNBC often generally restricts the stability of the therapeutic efficacy. To understand the heterogeneity and manage TNBC more precisely, multiple TNBC subtyping categories have been reported, providing the basis for profile-according therapeutic regimens. To provide more insight into targeting stem-like traits to ablate TNBC and reduce recurrence in the context of heterogeneity, this paper reviewed the molecular subtyping of TNBC, identified the consensus subtypes with distinct stem-like phenotypes, characterized the stemness hierarchy of TNBC, outlined the biological models for stem-like TNBC subtypes, summarized the therapeutic vulnerabilities in stem-like traits of the subtypes, and proposed potential therapeutic regimens targeting stem-like characteristics to improve TNBC prognosis.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Comparing different subtyping categories of TNBC. |
• | Proposing stemness hierarchy within TNBC subtypes. |
• | Outlining biological models of TNBC subtypes with enriched stemness. |
• | Stem-like traits as therapeutic vulnerabilities to treat TNBC in context of TNBC subtyping. |
Keywords : Triple negative breast cancer, Recurrence, Cancer stem-like traits, Molecular subtyping, Targeted therapy
Plan
Vol 174
Article 116584- mai 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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