Growth and differentiation factor-15: A link between inflammaging and cardiovascular disease - 27/04/24
Abstract |
Age-related disorders are closely linked to the accumulation of senescent cells. The senescence-associated secretory phenotype (SASP) sustains and progresses chronic inflammation, which is involved in cellular and tissue dysfunction. SASP-related growth and differentiation factor-15 (GDF-15) is an immunoregulatory cytokine that is coupled to aging and thus may have a regulatory role in the development and maintenance of atherosclerosis, a major cause of cardiovascular disease (CVD). Although the effects of GDF-15 are tissue-specific and dependent on microenvironmental changes such as inflammation, available data suggest that GDF-15 has a significant role in CVD. Thus, GDF-15 is a promising biomarker and potential therapeutic target for atherosclerotic CVD.
Le texte complet de cet article est disponible en PDF.Highlights |
• | GDF-15 regulates inflammation in several ways, contributing to inflammaging. |
• | It influences the progression of cardiovascular diseases through various pathways. |
• | Inflammation, endothelial dysfunction, and oxidative stress alter GDF-15 levels. |
• | GDF-15 can be used as a clinical and therapeutic target in age-related diseases. |
Keywords : Growth and differentiation factor-15, Aging, Inflammaging, Cardiovascular disease, Vascular inflammation
Plan
Vol 174
Article 116475- mai 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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