Autologous intraarterial pancreatic bone-marrow mononuclear cells infusion in T2D patients: Changes on beta-cells function, insulin resistance, and inflammatory marker - 26/04/24
, Imam Subekti a, b, Em Yunir a, b, Dante Saksono Harbuwono a, b, Dyah Purnamasari a, b, Tri Juli Edi Tarigan a, b, Wismandari Wisnu a, b, Dicky Levenus Tahapary a, b, Syahidatul Wafa a, b, Cindy Astrella c, Eunike Vania Christabel c, Anna Mira Lubis d, Ika Prasetya Wijaya e, Birry Karim e, Mohamad Syahrir Azizi e, Indrati Suroyo f, Sahat Matondang f, Krishna Pandu Wicaksono f, Dewi Wulandari g, Iqbal Fasha h, Cynthia Retna Sartika i, Cosphiadi Irawan d, h, Pradana Soewondo a, bAbstract |
Background |
Type 2 diabetes (T2D) is a progressive disease. Many drugs currently being used for the management of T2D have minimal effect on pancreatic beta cells regeneration. Cell-based therapies might provide potential benefits in this aspect.
Methods |
A pilot study in five T2D patients with 12 months follow-up was performed to evaluate the effect of autologous bone marrow mononuclear stem cells (BM-MNCs) infusion into pancreatic arteries on the insulin requirement, beta-cell function, insulin resistance, and systemic inflammatory marker (CRP).
Results |
The primary endpoint, a 50 % reduction of total insulin doses from baseline, was not achieved in this study. However, a trend of increasing fasting C-peptide (p = 0.07) and C-peptide 60′ (p = 0.07) and 90′ (p = 0.07) after a mixed-meal tolerance test was observed 12 months post-infusion compared to baseline levels. A similar result was observed for the homeostatic model assessment of beta cell function (HOMA1-B), an index for beta cell function. No improvement was observed for insulin resistance measured by homeostasis model assessment of insulin resistance (HOMA1-IR) and systemic inflammatory parameter.
Conclusion |
Intraarterial pancreatic autologous BM-MNCs infusion might potentially improve beta cell function in T2D patients, although further study is needed to confirm this finding.
Le texte complet de cet article est disponible en PDF.Keywords : Autologous bone marrow mononuclear stem cells, Intraarterial pancreas, Type 2 diabetes mellitus, Pancreatic beta-cells function, Insulin resistance
Plan
Vol 72 - N° 2
Article 103437- juin 2024 Retour au numéro
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