The prognostic nutritional index as a predictor of efficacy and early recurrence for adjuvant transarterial chemoembolization in hepatocellular carcinoma - 26/04/24
, Zhixiong Cai a, ⁎ Highlight |
• | A growth model was used to track changes in the prognostic nutritional index during the perioperative period. |
• | The trajectory of the prognostic nutritional index can help guide the selection of adjuvant TACE beneficiaries. |
• | Construction of a nomogram to predict prognosis in patients with HCC undergoing adjuvant TACE. |
• | The nomogram can effectively distinguish patients at high risk of recurrence from those at low risk. |
Abstract |
Background and aims |
Postoperative adjuvant transcatheter arterial chemoembolization (TACE) can prevent recurrence of hepatocellular carcinoma (HCC) in certain patients. This study aimed to identify the potential beneficiaries of adjuvant TACE.
Methods |
477 patients who underwent curative resection for HCC were enrolled in this retrospectively cohort study. The trajectory of the prognostic nutritional index (PNI) during the perioperative period was fitted using a latent-class growth mixed model. The association between adjuvant TACE and recurrence-free survival in each PNI group was assessed using the Kaplan-Meier curve. Furthermore, Cox regression analysis was conducted to identify the risk factors for early recurrence after adjuvant TACE and develop a nomogram model.
Results |
Patients in the PNI group III had a high risk of recurrence and could benefit from adjuvant TACE (P = 0.009). The prognostic prediction model for adjuvant TACE (PAT) incorporated eight variables (PNI, tumor size, tumor number, microvascular invasion, sex, aspartate aminotransferase, gamma-glutamyl transferase, and degree of differentiation). Patients with PAT score >330 and 235–330 had significantly higher recurrence rates than those with PAT score <235 (P < 0.001).
Conclusion |
PNI may help guide the selection of adjuvant TACE beneficiaries. PAT demonstrated a high accuracy in predicting the prognosis of patients who underwent postoperative TACE.
Le texte complet de cet article est disponible en PDF.Keywords : Prognostic nutritional index, Transcatheter arterial chemoembolization, Hepatocellular carcinoma
Abbreviations : AUC, PNI, TACE, HCC, AFP, BCLC, ALT, AST, GGT, CT, RFS, OS, HR, MVI, HBV
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Vol 48 - N° 6
Article 102344- juin 2024 Retour au numéro
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