The impact of COVID-19 on antibiotic resistance and clinical outcomes among critically ill patients - 20/04/24
, Farah A. Khraisat, MD b, Moayad N. Aldahabi, MD b, Ahmad Alghrabli, MD c, Yasmeen Khater, MD c, Noor Saleh, MD d, Thuraya N. Al-Sayegh, MD b, Asma S. Albtoosh, MD a
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Résumé |
Background |
There is conflicting evidence regarding the impact of the Coronavirus 2019 (COVID-19) pandemic on antimicrobial resistance, with few studies conducted in low- and middle-income countries. We investigated the impact of the COVID-19 pandemic on multidrug resistant organisms (MDROs) among critically ill patients and their clinical outcomes.
Methods |
This was a retrospective observational study of patients admitted to the medical Intensive Care Unit at Jordan University Hospital and had blood, urine, or bronchoalveolar bacterial cultures taken during 2 time periods: prepandemic (ie, 1/2016 to 1/2019) and pandemic (ie, 1/2020 to 1/2023). We compared the clinical outcomes (ie, in-hospital deaths, the need for O2 devices, intubation, the length of hospital stay, and the occurrence of complications) and prevalence of MDROs between the 2 periods and conducted multivariate analyses.
Results |
There were 1,254 patients (479 prepandemic and 775 postpandemic. The percentage of patients who had MDROs was significantly higher among patients with a culture taken during the pandemic (82.4%) compared to before it (17.6%) (P-value=.000). Multivariate analysis demonstrated that patients cultured during the pandemic were more than 3 times as likely to have an MDRO (odds ratio = 3.210; 95% confidence interval: 2.236-4.609).
Conclusions |
The increase in MDROs during the COVID-19 pandemic is an alarming threat to public health; thus, investigating the antibiotic resistance situation as the pandemic subsides is crucial.
Le texte complet de cet article est disponible en PDF.Highlights |
• | The impact of the COVID-19 pandemic on antibiotic resistance is controversial. |
• | Patients cultured during the pandemic were 3 times more likely to have an MDRO. |
• | Patients with cultures during the pandemic had worse clinical outcomes. |
Key Words : Human, Pandemic, Critically ill patients, Drug resistant organisms
Plan
| Conflicts of interest: None to report. |
Vol 52 - N° 5
P. 546-551 - mai 2024 Retour au numéro
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