Screening for asymptomatic nephrolithiasis in primary hyperparathyroidism patients is warranted - 17/04/24
Abstract |
Background |
We aimed to investigate the prevalence, characteristics, and management of nephrolithiasis in primary hyperparathyroidism (PHPT) patients.
Methods |
Medical records of patients who underwent parathyroidectomy at a tertiary care hospital in British Columbia from January 2016 to April 2023 were retrospectively reviewed. Demographic data, laboratory results, imaging reports, and urologic consultations were examined. Descriptive statistics and relevant statistical tests, including logistic regressions, were utilized for data analysis.
Result |
Of the 413 PHPT patients included in the study population, 41.9% harbored renal stones, and nearly half (48.6%) required urological interventions. Male sex, elevated preoperative serum ionized calcium (iCa) and 24-h urinary calcium (24 h urine Ca) levels were independent risk factors for stone formation. Additionally, male sex, younger age, and lower preoperative serum 25-hydroxyvitamin D (25(OH)D) level were associated with higher odds of requiring urological intervention for stones.
Conclusions |
This study identified significant prevalence of asymptomatic renal calcifications in PHPT patients, with a substantial proportion necessitating urological intervention. These findings emphasize the importance of incorporating screening and treatment of renal stones into the management of PHPT patients.
Le texte complet de cet article est disponible en PDF.Graphical abstract |
Highlights |
• | Of 413 hyperparathyroid study patients 41.9% had kidney stones. |
• | Preoperative renal US diagnosed a significant number of asymptomatic kidney stones. |
• | Routine renal imaging for all primary hyperparathyroidism patients is indicated. |
Keywords : Primary hyperparathyroidism, Nephrolithiasis, Kidney stones, Hypercalcemia
Plan
Vol 231
P. 91-95 - mai 2024 Retour au numéro
Article précédent
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