Metastasectomy for metastatic melanoma in the era of effective systemic therapy - 17/04/24
, Dale Han a, cAbstract |
Introduction |
Effective systemic therapy (EST) in patients with metachronous metastatic melanoma (MMM) improves survival and alters surgical decision-making. Surgical metastasectomy is another treatment option, however, it is unclear if metastasectomy confers survival benefit. This study seeks to identify any survival benefit associated with surgical management of MMM.
Methods |
Patients with MMM from 2009 to 2021 were grouped by receipt of metastasectomy and treatment era (pre-versus post-EST). Overall survival (OS) was calculated from date of metastasis and evaluated with Kaplan-Meier analysis.
Results |
Our dataset identified 226 patients with MMM; 32% were diagnosed pre-EST. On Kaplan-Meier analysis, OS was improved for patients undergoing treatment post-versus pre-EST (p < 0.001). In the post-EST era, metastasectomy was associated with an increase in OS compared to no resection (p = 0.022).
Conclusions |
In the post-EST group, EST paired with metastasectomy was associated with improved OS compared to the pre-EST group, suggesting persistent evidence of a survival benefit from metastasectomy.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Survival of metastatic melanoma is significantly improved in the era of effective systemic therapy (EST). |
• | Metastasectomy was associated with improved survival in both the pre- and post-EST groups. |
• | This suggests a persistent survival benefit from metastasectomy in the post-EST era. |
Keywords : Melanoma, Metastases, Metastasectomy, Systemic therapy
Plan
Vol 231
P. 65-69 - mai 2024 Retour au numéro
Article précédent
- The use of mobile thermal imaging and machine learning technology for the detection of early surgical site infections
- Beau J. Prey, Zachary T. Colburn, James M. Williams, Andrew D. Francis, Michael Vu, Daniel Lammers, John McClellan, Jason R. Bingham
- Breast conserving surgery combined with radiation therapy offers improved survival over mastectomy in early-stage breast cancer
- Elizaveta Vasilyeva, Alan Nichol, Brendan Bakos, Anise Barton, Michelle Goecke, Elaine Lam, Erin Martin, Caroline Lohrisch, Elaine McKevitt
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?