Referral and treatment patterns in pancreatic acinar cell carcinoma: A regional population-level analysis - 17/04/24
Abstract |
Background |
Pancreatic acinar cell carcinoma (PACC) is a rare exocrine tumor of the pancreas. We evaluated the effect disease stage, surgical intervention, and institutional volume status plays in survival.
Methods |
We queried the Oregon State Cancer Registry for patients with PACC from 1997 to 2018. Treatment and referral patterns were analyzed, and overall survival (OS) was evaluated with Kaplan-Meier and Cox-proportional hazard analysis.
Results |
43 patients were identified. Median OS was 33.1 and 7.1 months in those with locoregional and metastatic disease respectively (p = 0.008). Surgical intervention was associated with improved OS (hazard ratio 0.28, p < 0.0001). High volume center (HVC) care trended towards improving OS. While the majority of cases were diagnosed at low volume centers (74%), referral to HVCs was rare (n = 4) and limited to advanced (stage III/IV) disease.
Conclusion |
Stage and surgical resection influence survival outcomes in PACC, more data is needed to delineate the impact of institutional volume status.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Pancreatic acinar cell carcinoma (PACC) is a rare exocrine pancreatic malignancy. |
• | PACC carries an improved prognosis compared to pancreatic ductal adenocarcinoma. |
• | Surgical resection and disease stage impact survival in PACC. |
• | The impact of institutional volume status on survival remains unclear. |
Keywords : Survival, Treatment patterns, Referral center, Acinar cell carcinoma, Pancreas, Surgical resection
Plan
Vol 231
P. 55-59 - mai 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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