Metabolomic biomarkers of endometriosis: A systematic review - 13/04/24
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Highlights |
• | There are still no “gold standard” non‐invasive or minimally invasive tests available in clinical practice to accurately diagnose endometriosis. |
• | Metabolomics is aimed to identify and measure all metabolites. |
• | Metabolomic profile reflects metabolite pertubations caused by pathophysiological insult and might be a possible tool for disease biomarker identification. |
• | We identified a number of potential metabolomic biomarkers. |
• | Future studies should concentrate on exploration specific metabolites and comparison of concentration disturbances of the same agents between studies. |
Abstract |
The purpose of this systematic review was to identify potential metabolomic biomarkers of endometriosis in plasma, serum, peritoneal fluid, follicular fluid, urine, endometrial tissue samples of patients with endometriosis. Search was conducted in electronic databases including PubMed, The Cochrane Library, ClinicalTrials.gov, Embase, MEDLINE, Web of Science. Randomized controlled trials, observational, cohort and case control studies, comparing metabolomic profiles in women with laparoscopically confirmed endometriosis and women with laparoscopically confirmed absence of endometriosis were included. 17 studies were included in the qualitative synthesis. According to the results of our study, potential metabolomic biomarkers for the diagnosis of endometriosis were shown to be amino acids, including threonic acid and 3-hydroxybutyric acid, succinate, citrate, lactate, acetone, 3-hydroxybutyrate, acylcarnitines and sphingomyelins. Perturbations in metabolites levels reflect disruption of metabolic pathways in the presence of the disease. Due to the controversy of published data, further research and highlights are needed for the determination of specific metabolites.
Le texte complet de cet article est disponible en PDF.Keywords : Endometriosis, Metabolomics, Biomarkers, Metabolism
Plan
Vol 7
Article 100077- septembre 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.