Relationship of computed tomography-based measurements with symptom perception and quality of life in patients with severe asthma - 04/04/24
KoSAR investigators
Abstract |
Background |
Symptom perception and quality of life (QOL) are important domains for properly managing severe asthma. This study aimed to assess the relationship between airway structural and parenchymal variables measured using chest computed tomography (CT) and subjective symptom perception and QOL in patients with severe asthma enrolled in the Korean Severe Asthma Registry.
Methods |
This study used CT-based objective measurements, including airway wall thickness (WT), hydraulic diameter, functional small airway disease (fSAD), and emphysematous lung (Emph), to assess their association with subjective symptom (cough, dyspnea, wheezing, and sputum) perception measured using the visual analog scale, and QOL measured by the Severe Asthma Questionnaire (SAQ).
Results |
A total of 94 patients with severe asthma were enrolled in this study. The WT and fSAD% were significantly positively associated with cough and dyspnea, respectively. For QOL, WT and Emph% showed significant negative associations with the SAQ. However, there was no significant association between lung function and symptom perception or between lung function and QOL.
Conclusion |
Overall, WT, fSAD%, and Emph% measured using chest CT were associated with subjective symptom perception and QOL in patients with severe asthma. This study provides a basis for clarifying the clinical correlates of imaging-derived metrics and for understanding the mechanisms of respiratory symptom perception.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Symptom perception and QOL are important domains for managing severe asthma. |
• | There has been a growing focus on CT in the assessment of severe asthma. |
• | CT-based objective measurements include WT, fSAD% and Emph. |
• | WT and fSAD% were significantly positively associated with cough and dyspnea. |
• | WT and Emph% showed significant negative associations with the QOL. |
Keywords : Asthma, Cough, Dyspnea, Perception, Quality of life, Tomography scanners
Plan
Vol 225
Article 107598- avril 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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