Transmission of drug-resistant Mycobacterium tuberculosis isolates between Finnish- and foreign-born cases, 2014–2021: A molecular epidemiological study - 26/03/24
, Marjo Haanpera b, Silja Mentula b, Olli Vapalahti a, c, Hanna Soini b, Tarja Sironen a, c, Ravi Kant a, c, d, 1, Fathiah Zakham a, c, 1Abstract |
Background |
Data on the molecular epidemiology and transmission of drug-resistant Mycobacterium tuberculosis (MTB) in low-incidence settings with immigration from high-incidence settings is limited.
Method |
We included 115 drug-resistant (DR) MTB isolates with whole-genome sequencing data isolated in Finland between 2014 and 2021. Potential transmission clusters were identified using a threshold of 12 single-nucleotide polymorphisms (SNPs). Highly related clusters were identified using a threshold of 5 SNPs.
Result |
Of the 115 DR MTB isolates, 31 (27.0%) isolates were from Finnish-born cases and 84 (73.0%) were from foreign-born cases. The proportion of multidrug-resistant (MDR) MTB isolates (30/84, 35.7%) from foreign-born cases was higher than that of MDR MTB isolates from Finnish-born cases (8/31, 25.8%). Lineage 2 (40/115, 34.8%) and lineage 4 (40/115, 34.8%) were the most prevalent lineages. A total of 25 (21.7%) isolates were classified into eight potential transmission clusters (≤12 SNPs). Furthermore, five highly related clusters (≤5 SNPs) were identified, including three DR MTB isolates from Finnish-born cases and 14 DR isolates from foreign-born cases.
Conclusion |
The risk of DR MTB transmission between Finnish- and foreign-born persons is not negligible. Further research on clustering analysis in drug-susceptible MTB is worth to inform tuberculosis management and control in low-incidence settings with increasing immigration.
Le texte complet de cet article est disponible en PDF.Highlights |
• | MDR-TB is more prevalent among foreign-born DR-TB than Finnish-born DR-TB. |
• | Lineage 4 and lineage 2 were prevalent lineages in DR-TB cases in Finland. |
• | Transmission of DR MTB between Finnish- and foreign-born cases is uncommon. |
Keywords : Mycobacterium tuberculosis, Drug resistance, Mutation, Whole genome sequencing, Genetic cluster
Plan
Vol 146
Article 102492- mai 2024 Retour au numéro
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