Maternal and neonatal outcomes of French prospective multicenter cohort study COVIPREG during the first two COVID-19 waves - 24/03/24

Doi : 10.1016/j.jogoh.2024.102764

Alexandre J. Vivanti ^a,^b, Camille Couffignal ^c,^d, Jeanne Sibiude ^d,^e, Anne-Gael Cordier ^b,^f,^u, Vassilis Tsatsaris ^g, Flore Rozenberg ^h, Odile Launay ⁱ, Alexandra Benachi ^a, Daniele De Luca ^j, Pierre-Yves Ancel ^k, Estelle Marcault ^l, Yves Ville ^m, Julie Carrara ^a, Dominique Luton ⁿ, Marc Dommergues ^o,^v, Constance Borie ^p, Gilles Kayem ^q, Laurence Lecomte ^k, Marianne Leruez-Ville ^r, Claire Périllaud-Dubois ^d,^s, Valérie Biran ^t, Pauline Manchon ^c, Olivier Picone ^b,^d,^e, Christelle Vauloup-Fellous ^b,^s,^w,^⁎
^a Service de Gynécologie-Obstétrique, AP-HP, Hôpital Antoine Béclère, F-92140 Clamart, Université Paris-Saclay, Gif-sur-Yvette France
^b Groupe de Recherche sur les Infections Pendant la Grossesse (GRIG), Paris, France
^c Université de Paris, F-75006 Paris, France
^d IAME U1137, Inserm, Université Paris Cité, Paris, France
^e Maternité, AP-HP, Hôpital Louis Mourier, F-75007 Paris, France
^f Université Paris-Saclay, 91190 Gif-sur-Yvette, France
^g Service de Gynécologie-Obstétrique, AP-HP, Hôpital Cochin Port Royal, F-75007 Paris, France
^h Laboratoire de Virologie, AP-HP, Hôpital Cochin, F-75014 Paris, France
ⁱ CIC vaccinologie, AP-HP, FHU PREMA, Hôpital Cochin, F-75014 Paris, France
^j Réanimation néonatale, AP-HP, Hôpital Antoine Béclère, F-92140 Clamart, France
^k Unité de recherche clinique, CIC-Mère enfant, AP-HP, FHU PREMA, Hôpital Cochin, F-75014 Paris, France
^l Unité de recherche clinique PNVS, AP-HP, Hôpital Bichat, F-75018 Paris, France
^m Maternité, AP-HP, Hôpital Necker, F-75007 Paris, France
ⁿ Maternité, AP-HP, Hôpital Bichat, F-75018 Paris, France
^o Sorbonne Université, F-75006 Paris, France
^p Maternité, AP-HP, Hôpital Robert Debré, F-75019 Paris, France
^q Maternité, AP-HP, Hôpital Trousseau, F-75012 Paris, France
^r Laboratoire de Virologie, AP-HP, Hôpital Necker, F-75007 Paris, France
^s Université Paris-Saclay, INSERM U1193, 94804 Villejuif, France
^t Réanimation néonatale, AP-HP, Hôpital Robert Debré, F-75019 Paris, France
^u Maternité, AP-HP, Hôpital Bicêtre, F-94270 Le Kremlin-Bicêtre, France
^v Maternité, AP-HP, Hôpital Pitié-Salpêtrière, F-75013 Paris, France
^w Laboratoire de Virologie, AP-HP, Hôpital Paul-Brousse, F-94804 Villejuif, France

^⁎Corresponding author : Laboratoire de Virologie, Hôpital Paul Brousse, GHU Paris Saclay, AP-HP, 12 avenue Paul Vaillant Couturier, 94800 Villejuif FranceLaboratoire de Virologie, Hôpital Paul Brousse, GHU Paris Saclay, AP-HP12 avenue Paul Vaillant CouturierVillejuif94800France

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Abstract

Background

SARS-CoV-2 infection on pregnant women was the subject of many questions since the COVID-19 pandemic.

Methods

We aim to assess maternal and neonatal outcomes of SARS-CoV-2 infection contracted during 2nd and 3rd trimesters of pregnancy during the first two COVID-19 waves across a prospective French multicenter cohort study. Patients were included between April 2020 and January 2021 in 10 maternity hospitals in Paris area with two groups (i) pregnant women with a positive SARS-CoV-2 nasopharyngeal RT-PCR between [14WG; 37WG[(symptomatic infection), (ii) pregnant women with a negative serology (or equivocal) at delivery and without a positive SARS-CoV-2 nasopharyngeal RT-PCR at any time during pregnancy (G2 group)

Main findings

2410 pregnant women were included, of whom 310 had a positive SARS-CoV-2 nasopharyngeal RT-PCR and 217 between [14WG; 37WG[. Most infections occurred between 28 and 37 weeks of gestation (56 %). Most patients could be managed as outpatients, while 23 % had to be hospitalized. Among women with a positive RT-PCR, multiparous women were over-represented (OR = 2.45[1.52;3.87]); were more likely to deliver before 37 weeks of gestation (OR = 2.19[1.44;3.24]) and overall cesarean deliveries were significantly increased (OR = 1.53[1.09;2.13]).

Conclusions

This study highlights the maternal, obstetrical, and neonatal burden associated with SARS-CoV-2 infections during the first two pandemic waves before availability of vaccines.

Trial registration

NCT04355234 (registration date: 21/04/2020)

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Keywords : Sars-cov-2, Pregnancy, Preterm delivery, Maternal and neonatal outcomes, RT-PCR

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Vol 53 - N° 6

Article 102764- juin 2024 Retour au numéro

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Maternal and neonatal outcomes of French prospective multicenter cohort study COVIPREG during the first two COVID-19 waves - 24/03/24

Abstract

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Methods

Main findings

Conclusions

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Plan

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