Recent advances in application of computer-aided drug design in anti-COVID-19 Virials Drug Discovery - 22/03/24
Abstract |
Corona Virus Disease 2019 (COVID-19) is a global pandemic epidemic caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which poses a serious threat to human health worldwide and results in significant economic losses. With the continuous emergence of new virus strains, small molecule drugs remain the most effective treatment for COVID-19. The traditional drug development process usually requires several years; however, the development of computer-aided drug design (CADD) offers the opportunity to develop innovative drugs quickly and efficiently. The literature review describes the general process of CADD, the viral proteins that play essential roles in the life cycle of SARS-CoV-2 and can serve as therapeutic targets, and examples of drug screening of viral target proteins by applying CADD methods. Finally, the potential of CADD in COVID-19 therapy, the deficiency, and the possible future development direction are discussed.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Medication is the key therapeutic option for dealing with COVID-19. |
• | The key structural proteins of SARS-CoV-2 can be used as drug targets. |
• | CADD develops small molecule drugs that target key viral proteins. |
Keywords : Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) virus, Corona Virus Disease 2019 (COVID-19), Drug discovery, Computer-aided drug design (CADD)
Plan
Vol 173
Article 116423- avril 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.