Painful diabetic neuropathy: The role of ion channels - 22/03/24
Abstract |
Painful diabetic neuropathy (PDN) is a common chronic complication of diabetes that causes neuropathic pain and negatively affects the quality of life. The management of PDN is far from satisfactory. At present, interventions are primarily focused on symptomatic treatment. Ion channel disorders are a major cause of PDN, and a complete understanding of their roles and mechanisms may provide better options for the clinical treatment of PDN. Therefore, this review summarizes the important role of ion channels in PDN and the current drug development targeting these ion channels.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Multiple ion channels are involved in the development of painful diabetic neuropathy. |
• | Ion channel disorders are an important cause of painful diabetic neuropathy. |
• | Drugs that target ion channels can be used to treat painful diabetic neuropathy. |
Abbreviations : AMPAR, Cav, CNS, DRG, FFA, GABA, GLUT, HCN, IP, IPL, IT, IV, KATP, Kir, Kv, MCT, Nav, NMDA, PDN, PNS, SC, STZ, SUR, T1DM, T2DM, TRP, VSD
Keywords : Painful diabetic neuropathy, Ion channels, Neuropathic pain, Mechanisms, Drug
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Vol 173
Article 116417- avril 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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