Paeonol promotes longevity and fitness in Caenorhabditis elegans through activating the DAF-16/FOXO and SKN-1/Nrf2 transcription factors - 22/03/24
, Mingfang Tao b, ⁎ Abstract |
Paeonol, as one of the most abundant plant-derived polyphenols, has multiple bioactivities including anti-inflammatory, anti-tumor, and anti-cardiovascular diseases. Nevertheless, the anti-aging effects and related mechanisms of paeonol are rarely reported. In this study, we found that paeonol significantly prolonged the mean lifespan of Caenorhabditis elegans (C. elegans) by 28.49% at a dose of 200 μM. Moreover, paeonol promoted the health of C. elegans by increasing the body bending and pharyngeal pumping rates and reducing the lipofuscin accumulation level. Meanwhile, paeonol induced the expression of stress-related genes or proteins by activating the transcription factors DAF-16/FOXO, SKN-1/Nrf2, and HSF-1, which in turn enhanced oxidative and thermal stress tolerance. The mechanism behind the anti-aging effect of paeonol occurred by down-regulating the insulin/IGF-1 signaling (IIS) pathway. Our findings shed new light on the application of paeonol for longevity promotion and human health.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Paeonol significantly increased lifespan and improved healthspan in C. elegans. |
• | In vivo anti-aging effect of Paeonol was investigated for the first time. |
• | Paeonol extended the lifespan of C. elegans by down-regulating the IIS pathway. |
• | Paeonol promoted longevity by activating DAF-16/FOXO and SKN-1/Nrf2. |
Abbreviations : C. elegans, ⅡS, DMSO, SOD, GSH, QRT-PCR, HSPs
Keywords : Caenorhabditis elegans, Anti-aging, Paeonol, Stress resistance, IIS pathway
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Vol 173
Article 116368- avril 2024 Retour au numéro
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