Targeting neutrophil extracellular traps: A novel strategy in hematologic malignancies - 22/03/24
Abstract |
Neutrophil extracellular traps (NETs) have emerged as a critical factor in malignant hematologic disease pathogenesis. These structures, comprising DNA, histones, and cytoplasmic proteins, were initially recognized for their role in immune defense against microbial threats. Growing evidence suggests that NETs contribute to malignant cell progression and dissemination, representing a double-edged sword. However, there is a paucity of reports on its involvement in hematological disorders. A comprehensive understanding of the intricate relationship between malignant cells and NETs is necessary to explore effective therapeutic strategies. This review highlights NET formation and mechanisms underlying disease pathogenesis. Moreover, we discuss recent advancements in targeted inhibitor development for selective NET disruption, empowering precise design and efficacious therapeutic interventions for malignant hematologic diseases.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Neutrophil extracellular traps are a double-edged sword in malignant hematologic disease. |
• | The structure of NET includes DNA, histones and cytoplasmic proteins. |
• | Targeting neutrophil extracellular traps is a new strategy for hematologic malignancy therapy. |
Keywords : Neutrophil extracellular traps, Hematologic malignancies, Targeted inhibitor, Therapeutic strategy
Plan
Vol 173
Article 116334- avril 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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