The potential role of the triglyceride-glucose index in left ventricular systolic function and in-hospital outcomes for patients with acute myocardial infarction - 21/03/24
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Graphical abstract |
Highlights |
• | The TyG index was associated with in-hospital MACE for patients with AMI. |
• | LVEF significantly modified the association between the TyG index and MACE in AMI. |
• | The TyG index + LVEF was helpful for risk stratification of patients with AMI. |
• | The TyG index + LVEF enhanced the predictive ability of the GRACE score for MACE. |
Abstract |
Background |
A limited number of small-sample cohort studies have investigated the association between the triglyceride-glucose index and in-hospital prognosis. Moreover, the translational potential role of left ventricular systolic function – measured by left ventricular ejection fraction – combined with the triglyceride-glucose index in prioritizing patients with acute myocardial infarction at high risk of in-hospital major adverse cardiovascular events remains unknown.
Aim |
To explore the potential role of the triglyceride-glucose index in left ventricular systolic function and in-hospital major adverse cardiovascular events in patients with acute myocardial infarction.
Methods |
The Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome project (CCC-ACS) was analysed for this study.
Results |
We included 43,796 patients with acute myocardial infarction. Patients with a higher triglyceride-glucose index showed an increased risk of major adverse cardiovascular events (adjusted odds ratio 1.46, 95% confidence interval 1.31–1.63). Interaction analyses revealed that left ventricular ejection fraction modified the relationship between the triglyceride-glucose index and major adverse cardiovascular events. Furthermore, patients with acute myocardial infarction were categorized by the triglyceride-glucose index and left ventricular ejection fraction; the low left ventricular ejection fraction/high triglyceride-glucose index group showed the highest risk of major adverse cardiovascular events (adjusted odds ratio 2.14, 95% confidence interval 1.58–2.89).
Conclusions |
In a comprehensive nationwide acute myocardial infarction registry conducted in China, a higher triglyceride-glucose index was found to be associated with in-hospital major adverse cardiovascular events, and this was particularly evident among patients with a lower left ventricular ejection fraction. Moreover, the triglyceride-glucose index combined with left ventricular ejection fraction was helpful for risk stratification of patients with acute myocardial infarction.
Le texte complet de cet article est disponible en PDF.Keywords : Triglyceride-glucose index, Acute myocardial infarction, Major adverse cardiovascular events, Left ventricular ejection fraction, Energy metabolism interventions
Plan
☆ | Tweet: In the CCC-ACS project, we found the translational potential role of the TyG index in LV systolic function and AMI outcomes. Thanks to everyone who contributed to this work. |
Vol 117 - N° 3
P. 204-212 - mars 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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