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Predictors of cardiac arrest in severe accidental hypothermia - 19/03/24

Doi : 10.1016/j.ajem.2024.01.031 
Paweł Podsiadło, MD PhD a, , Tomáš Brožek, MD PhD b, Martin Balik, MD PhD b, Ewelina Nowak, PhD c, Konrad Mendrala, MD PhD d, Hubert Hymczak, MD PhD e, Wojciech Dąbrowski, MD Prof f, Bartosz Miazgowski, MD g, Aleksander Rutkiewicz, MD PhD h, Marian Burysz, MD PhD i, Anna Witt-Majchrzak, MD PhD j, Tomasz Jędrzejczak, MD PhD k, Rafał Podsiadło, MD l, Tomasz Darocha, MD Prof d

Hypothermia Study Group

Kacper Reszka 1, Guillaume Debaty 2, Nicolas Segond 2, Michał Dudek 3, Radosław Litwinowicz 4, Stanisław Górski 5, Sylweriusz Kosiński 6, Roch Pakuła 7
1 Department of Anesthesiology and Intensive Care, University Hospital, Łódź, Poland 
2 Univ. Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, CHU Grenoble Alpes, TIMC, Grenoble, France 
3 Department of Emergency Medicine, Faculty of Health Sciences, University of Bielsko-Biała, Poland 
4 Departament of Cardiac Surgery, Dr. Władysław Biegański Regional Specialist Hospital, Grudziądz, Poland 
5 Department of Medical Education, Jagiellonian University Medical College, Kraków, Poland 
6 Department of Intensive Interdisciplinary Therapy, Jagiellonian University Collegium Medicum, Krakow, Poland 
7 Department of Cardiac Surgery, Heart and Lung Transplantation and Mechanical Circulatory Support, Silesian Center for Heart Diseases, Medical University of Silesia, Katowice, Poland 

a Department of Emergency Medicine, Jan Kochanowski University, Kielce, Poland 
b Department of Anaesthesiology and Intensive Care, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic 
c Institute of Health Sciences, Jan Kochanowski University, Kielce, Poland 
d Department of Anaesthesiology and Intensive Care, Medical University of Silesia, Katowice, Poland 
e Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Kraków University, Kraków, Poland 
f Department of Anaesthesiology and Intensive Care, Medical University of Lublin, Poland 
g Emergency Department, University Hospital, Pomeranian Medical University, Szczecin, Poland 
h Department of Anaesthesiology and Intensive Care, Cieszyn, Poland 
i Departament of Cardiac Surgery, Dr. Władysław Biegański Regional Specialist Hospital, Grudziądz, Poland 
j Department of Cardiac Surgery Provincial Specialist Hospital, Olsztyn, Poland 
k Department of Cardiosurgery, Pomeranian Medical University in Szczecin, Poland 
l Department of Anaesthesiology and Intensive Care, University Hospital, Wrocław, Poland 

Corresponding author at: Department of Emergency Medicine, Jan Kochanowski University, al. IX Wieków Kielc 19A, Kielce, Poland.Department of Emergency MedicineJan Kochanowski Universityal. IX Wieków Kielc 19AKielcePoland

Abstract

Study objective

To indicate predictors of witnessed hypothermic cardiac arrest.

Methods

We conducted a retrospective analysis of 182 patients with severe accidental hypothermia (i.e., with core body temperature of ≤28 °C) who presented with preserved spontaneous circulation at first contact with medical services. We divided the study population into two groups: patients who suffered hypothermic cardiac arrest (HCA) at any time between encounter with medical service and restoration of normothermia, and those who did not sustain HCA. The analyzed outcome was the occurrence of cardiac arrest prior to achieving normothermia. Hemodynamic and biochemical parameters were analyzed with regard to their association with the outcome.

Results

Fifty-two (29%) patients suffered HCA. In a univariable analysis, four variables were significantly associated with the outcome, namely heart rate (p < 0.001), systolic blood pressure (p = 0.03), ventricular arrhythmia (p = 0.001), and arterial oxygen partial pressure (p = 0.002). In the multivariable logistic regression the best model predicting HCA included heart rate, PaO2, and Base Excess (AUROC = 0.78). In prehospital settings, when blood gas analysis is not available, other multivariable model including heart rate and occurrence of ventricular arrhythmia (AUROC = 0.74) can be used. In this study population, threshold values of heart rate of 43/min, temperature-corrected PaO2 of 72 mmHg, and uncorrected PaO2 of 109 mmHg, presented satisfactory sensitivity and specificity for HCA prediction.

Conclusions

In patients with severe accidental hypothermia, the occurrence of HCA is associated with a lower heart rate, hypoxemia, ventricular arrhythmia, lower BE, and lower blood pressure. These parameters can be helpful in the early selection of high-risk patients and their allocation to extracorporeal rewarming facilities.

Le texte complet de cet article est disponible en PDF.

Keywords : Accidental hypothermia, Cardiac arrest, Rescue collapse, Resuscitation, Rewarming, Blood gas analysis


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