Rechercher
image du produit
Diabetes & Metabolism

S'abonner

Associations of type 2 diabetes and the risk of migraine in Chinese populations - 16/03/24

Doi : 10.1016/j.diabet.2024.101518 
Jielong Wu a, h, i, 1, Jie Fang a, b, c, d, e, f, g, 1, Xiaodong Yuan j, Lingshan Ma a, h, i, Liangcheng Zheng a, b, c, d, e, f, g, Qing Lin a, b, c, d, e, f, g, Xingkai An a, b, c, d, e, f, g, Zhanxiang Wang c, d, e, f, g, h, i, k, Qilin Ma a, b, c, d, e, f, g, h, i, ⁎
a Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China 
b The School of Clinical Medicine, Fujian Medical University, China 
c Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, China 
d Xiamen Key Laboratory of Brain Center, China 
e Xiamen Medical Quality Control Center for Neurology, China 
f Fujian Provincial Clinical Research Center for Brain Diseases, China 
g Xiamen Clinical Research Center for Neurological Diseases, China 
h School of Medicine, Xiamen University, China 
i National Institute for Data Science in Health and Medicine, Xiamen University, China 
j Department of Gynecology of Xiamen Maternal and Child Health Care Hospital, China 
k Department of Neurosurgery and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China 

⁎Corresponding author at: Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen 361003, China.Department of Neurology and Department of NeuroscienceThe First Affiliated Hospital of Xiamen University55 Zhenhai RoadXiamen361003China

Highlights

•
Type 2 diabetes mellius (T2DM) and migraine are common and complex comorbid disorders.
•
We investigated the association between T2DM and migraine risk in a Chinese cohort.
•
T2DM reduced the risk of migraine.
•
Patients with migraine and T2DM experienced significant headache symptom relief.
•
The study findings suggest the necessity of related mechanistic research.

Le texte complet de cet article est disponible en PDF.

Abstract

Aim

We aimed to explore the relationship between type 2 diabetes mellitus (T2DM) and the incidence rate of migraine in a Chinese population, and analyze the clinical characteristics of migraine patients with T2DM.

Methods

Data on the study cohort of 9873 individuals were obtained from the China Health and Retirement Longitudinal Study (CHARLS). The incidence rate of migraine from 2015 to 2018 was assessed. The Cox proportional hazards model was used to estimate hazard ratios (HRs) and their 95% confidence intervals (CIs) for the relationship between T2DM and the incidence of migraine. In addition, a cross-sectional study including 168 migraine patients was conducted in Xiamen, China. Migraine patients were grouped according to their T2DM status. Multivariable linear regression models were used to estimate βs and their 95% CIs for the relationship between migraine characteristics and T2DM.

Results

The cumulative incidence rate of migraine from 2015 to 2018 in the T2DM group and control group was 7.26% [6.04%.8.65%] and 8.91% [8.27%.9.58%], respectively. The risk of migraine in patients with T2DM was reduced by 21% (HR 0.79 [0.65;0.95]) compared to patients with no T2DM after adjustment for confounders. The cross-sectional study showed that the presence of T2DM significantly reduced migraine frequency and relieved migraine intensity.

Conclusion

This was the first study to validate that T2DM reduced the risk of migraine in a Chinese population cohort. Patients with migraine and T2DM may experience significant relief from their headache symptoms. Carrying out relevant mechanistic research may help to identify new targets for migraine treatment and contribute to further understanding the impact of T2DM or related metabolic disorders on an individual's health.

Le texte complet de cet article est disponible en PDF.

Keywords : Chinese population cohort, Migraine, Migraine characteristics, Type 2 diabetes mellitus

Abbreviations : T2DM, CHARLS, HR, CVD, IDF, ICHD-3, CESD-10, CI, INSR, GWAS, PheWAS, IHGC, GWAS-PW, CGRP


Plan


© 2024  Elsevier Masson SAS. Tous droits réservés.
Ajouter à ma bibliothèque Retirer de ma bibliothèque Imprimer
Export

    Export citations

  • Fichier

    •

  • Contenu

    •

Vol 50 - N° 2

Article 101518- mars 2024 Retour au numéro
Article précédent Article précédent
  • Social isolation, loneliness, and the risk of incident type 2 diabetes mellitus by glycemic status
  • Yanjun Zhang, Mengyi Liu, Chun Zhou, Ziliang Ye, Yuanyuan Zhang, Sisi Yang, Panpan He, Xiaoqin Gan, Xianhui Qin
| Article suivant Article suivant
  • High serum total bilirubin as a potential protective factor for gestational diabetes mellitus: A retrospective cohort study of 92,885 Chinese pregnant women
  • Yan Zhao, Wenyu Zhu, Miao Wang, Luyi Cai, Xueying Zheng, Liping Jin

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL

EM-CONSULTE.COM est déclaré à la CNIL, déclaration n° 1286925.

En application de la loi nº78-17 du 6 janvier 1978 relative à l'informatique, aux fichiers et aux libertés, vous disposez des droits d'opposition (art.26 de la loi), d'accès (art.34 à 38 de la loi), et de rectification (art.36 de la loi) des données vous concernant. Ainsi, vous pouvez exiger que soient rectifiées, complétées, clarifiées, mises à jour ou effacées les informations vous concernant qui sont inexactes, incomplètes, équivoques, périmées ou dont la collecte ou l'utilisation ou la conservation est interdite.
Les informations personnelles concernant les visiteurs de notre site, y compris leur identité, sont confidentielles.
Le responsable du site s'engage sur l'honneur à respecter les conditions légales de confidentialité applicables en France et à ne pas divulguer ces informations à des tiers.

Tout le contenu de ce site: Copyright © 2024 Elsevier, ses concédants de licence et ses contributeurs. Tout les droits sont réservés, y compris ceux relatifs à l'exploration de textes et de données, a la formation en IA et aux technologies similaires. Pour tout contenu en libre accès, les conditions de licence Creative Commons s'appliquent.