Altered IgG4 antibody response to repeated mRNA versus recombinant protein SARS-CoV-2 vaccines - 15/03/24
Doi : 10.1016/j.jinf.2024.106119
Raj Kalkeri ⁎ 
, Mingzhu Zhu, Shane Cloney-Clark, Joyce S. Plested, Anand Parekh, Drew Gorinson, Rongman Cai, Soham Mahato
, Mingzhu Zhu, Shane Cloney-Clark, Joyce S. Plested, Anand Parekh, Drew Gorinson, Rongman Cai, Soham Mahato Novavax, Inc., Gaithersburg, MD, USA
⁎Corresponding author.
Pradhipa Ramanathan, Lidwina Carissa Aurelia, Kevin John Selva
Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia
Amy W. Chung
Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia
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Graphical abstract |
Highlights |
• | In agreement with recently published studies, repeated mRNA SARS-CoV-2 vaccination was associated with an increase in Spike-specific IgG4. |
• | By contrast, IgG4 class switch was not observed following four doses of Novavax protein-based SARS-CoV-2 vaccine. |
• | SARS-CoV-2 specific IgG3, an IgG subclass known to induce potent neutralization and Fc functions, was higher after Novavax (>10x vs. mRNA). |
• | In contrast to the mRNA homologous regimens, Novavax homologous and heterologous vaccinations evoked stronger Fcγ effector activities. |
© 2024
The Author(s). Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 88 - N° 3
Article 106119- mars 2024 Retour au numéro
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