Exploring the combined effects of MTTP gene polymorphisms in chronic hepatitis C patients with hepatic steatosis - 07/03/24
Doi : 10.1016/j.clinre.2024.102291
Thamiris Vaz Gago Prata a, Victória Gonçalves de Paula a, Lhays Ozório Passos a, Vitória Luiza Batalhoti Brogiato a, Gustavo Manoel Ferreira a, Caroline Manchiero a, b, Bianca Peixoto Dantas a, b, Débora Bignotto Rosane Battaglia a, Gerusa Maria Figueiredo b, c, Fátima Mitiko Tengan a, d, Mariana Cavalheiro Magri a, b, ⁎ 
a Laboratorio de Investigacao Medica em Hepatologia por Virus (LIM-47), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
b Instituto de Medicina Tropical de Sao Paulo, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
c Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
d Departamento de Molestias Infecciosas e Parasitarias, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
⁎Corresponding author at: Laboratorio de Investigacao Medica em Hepatologia por Virus (LIM-47), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar, 470 - Instituto de Medicina Tropical - Predio 2. Bairro Cerqueira Cesar. Sao Paulo, SP, Brazil.Laboratorio de Investigacao Medica em Hepatologia por Virus (LIM-47)Hospital das Clinicas HCFMUSP, Faculdade de MedicinaUniversidade de Sao PauloAv. Dr. Eneas de Carvalho Aguiar, 470 - Instituto de Medicina Tropical - Predio 2. Bairro Cerqueira CesarSao PauloSPBrazil
Highlights |
• | The consequences of chronic hepatitis c may depend on the effect of several factors. |
• | 53 % of patients with chronic hepatitis c had hepatic steatosis. |
• | The −164T/C and −493 G/T polymorphisms in the MTTP gene showed a combined effect on steatosis. |
• | This combined effect may increase the chance of presenting steatosis by 12.83 times. |
Keywords : Hepatitis C virus (HCV), Hepatic steatosis, Interaction, Microsomal triglyceride transfer protein (MTTP), Polymorphisms
Plan
© 2024
Publié par Elsevier Masson SAS.
Vol 48 - N° 3
Article 102291- mars 2024 Retour au numéro
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