Desired properties of polymeric hydrogel vitreous substitute - 29/02/24
Abstract |
Vitreous replacement is a commonly employed method for treating a range of ocular diseases, including posterior vitreous detachment, complex retinal detachment, diabetic retinopathy, macular hole, and ocular trauma. Various clinical substitutes for vitreous include air, expandable gas, silicone oil, heavy silicone oil, and balanced salt solution. However, these substitutes have drawbacks such as short retention time, cytotoxicity, high intraocular pressure, and the formation of cataracts, rendering them unsuitable for long-term treatment. Polymeric hydrogels possess the potential to serve as ideal vitreous substitutes due to their structure-mimicking to natural vitreous and adjustable mechanical properties. Replacement with hydrogels as the tamponade can help maintain the shape of the eyeball, apply pressure to the detached retina, and ensure the metabolic transport of substances without impairing vision. This literature review examines the required properties of artificial vitreous, including the optical properties, rheological properties, expansive force action, and physiological and biochemical functions of chemically and physically crosslinked hydrogels. The strategies for enhancing the biocompatibility and injectability of hydrogels are also summarized and discussed. From a clinical ophthalmology perspective, this paper presents the latest developments in vitreous replacement, providing clinicians with a comprehensive understanding of hydrogel clinical applications, which offers guidance for future design directions and methodologies for hydrogel development.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Comprehensively describing the hydrogels properties for vitreous substitute from the viewpoint of a clinical ophthalmologist. |
• | Sorting out the original materials, cross-linking methods, rheology, and degradation ability of the materials to analyze. |
• | Demonstrating the versatility and accuracy of in vitro biocompatibility testing of hydrogel materials. |
• | Discussing hydrogels with biochemical functions through drug-carrying or functional groups to reduce vitrectomy complications. |
Keywords : Vitreous substitute, Polymers, Hydrogel, Vitreous body, Artificial vitreous, Eye
Plan
Vol 172
Article 116154- mars 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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