Tumor-specific cytolysis by peptide-conjugated echogenic polymer micelles - 29/02/24
Abstract |
Interest in multifunctional polymer nanoparticles for targeted delivery of anti-cancer drugs has grown significantly in recent years. In this study, tumor-targeting echogenic polymer micelles were prepared from poly(ethylene glycol) methyl ether-alkyl carbonate (mPEG-AC) derivatives, and their potential in cancer therapy was assessed. Various mPEG derivatives with carbonate linkages were synthesized via an alkyl halide reaction between mPEG and alkyl chloroformate. Micelle formation using polymer amphiphiles in aqueous media and the subsequent carbon dioxide (CO2) gas generation from the micelles was confirmed. Their ability to target neuroblastoma was substantially enhanced by incorporating the rabies virus glycoprotein (RVG) peptide. RVG-modified gas-generating micelles significantly inhibited tumor growth in a tumor-bearing mouse model owing to CO2 gas generation within tumor cells and resultant cytolytic effects, showing minimal side effects. The development of multifunctional polymer micelles may offer a promising therapeutic approach for various diseases, including cancer.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | CO2-generating polymer micelles are prepared from PEG-alkyl carbonates. |
• | CO2 release depends on PEG length and alkyl chloroformate type. |
• | RVG-PEG micelles exhibit enhanced neuroblastoma targeting. |
• | RVG-PEG micelles significantly suppress tumor growth in a mouse model. |
Keywords : Poly(ethylene glycol), Alkyl carbonate, Micelle, Gas-generation, Cytolysis, Cancer therapy
Plan
Vol 172
Article 116272- mars 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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