Beneficial effect of honokiol and magnolol on polyol pathway and oxidative stress parameters in the testes of diabetic rats - 29/02/24
Abstract |
In diabetes hyperglycemia, excessive production of free radicals and present oxidative stress lead to many complications in the body, including male reproductive system disorders. To prevent the development of diabetic complications in the testes resulting from them, it seems beneficial to include compounds considered as natural antioxidants. Honokiol and magnolol are neolignans obtained from magnolia bark, which possess proven antioxidant properties. The aim of this study was to evaluate the effect of honokiol and magnolol on the parameters of oxidative stress, polyol pathway and glycation products in the testes as well as on selected biochemical parameters in the blood serum of rats with type 2 diabetes. The study was conducted on mature male Wistar rats with high fat diet and streptozotocin-induced type 2 diabetes. Neolignans-treated rats received honokiol or magnolol orally at the doses of 5 or 25 mg/kg, respectively, for 4 weeks. Parameters related to glucose and lipid homeostasis, basic serological parameters and sex hormones level in the serum as well as polyol pathway parameters, antioxidant enzyme activity, endogenous antioxidants level, sumaric parameters for oxidative stress and oxidative damage in the testes were estimated. Oral administration of honokiol and magnolol turned out to be beneficial in combating the effects of oxidative stess in the testes, but showed no favorable effects on serum biochemical parameters. Additionally, magnolol compared to honokiol revealed more advantageous impact indicating the reversal of the effects of diabetic complications in the male reproductive system and counteracted oxidative stress damages and polyol pathway disorders in the testes.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Diabetes and oxidative stress contribute to male reproductive system disorders. |
• | Endogenous defense systems in rat testes and serum are deficient in diabetes. |
• | Honokiol and magnolol prevent the effects of diabetic oxidative stress in the testes. |
• | Magnolol treatment counteracts changes in the polyol pathway in the testes. |
• | Neolignans do not improve the serum biochemical parameters disturbed by diabetes. |
Abbreviations : AGEs, ALP, ALT, ANOVA, AOPP, AR, AST, C group, CAT, DM group, DTNB, FR, GPx, GSH, HDL, HFD, HOMA-IR, HON, HON5, HON25, LDH, LDL, LH, LSD, MAG, MAG5, MAG25, MDA, NADPH, NPSH, OS, OSI, QUICKI, SDH, SEM, SOD, STZ, TAC, TAR, TBARS, TG, TOS, total SH, VIT C
Keywords : Honokiol, Magnolol, Diabetes, Oxidative stress, Testes
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Vol 172
Article 116265- mars 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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