Targeting the JAK2/STAT3 signaling pathway with natural plants and phytochemical ingredients: A novel therapeutic method for combatting cardiovascular diseases - 29/02/24
Abstract |
The aim of this article is to introduce the roles and mechanisms of the JAK2/STAT3 pathway in various cardiovascular diseases, such as myocardial fibrosis, cardiac hypertrophy, atherosclerosis, myocardial infarction, and myocardial ischemia-reperfusion. In addition, the effects of phytochemical ingredients and different natural plants, mainly traditional Chinese medicines, on the regulation of different cardiovascular diseases via the JAK2/STAT3 pathway are discussed. Surprisingly, the JAK2 pathway has dual roles in different cardiovascular diseases. Future research should focus on the dual regulatory effects of different phytochemical ingredients and natural plants on JAK2 to pave the way for their use in clinical trials.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Describe the mechanism of JAK2/STAT3 signaling pathway in cardiovascular disease. |
• | Explore the natural plants and phytochemical ingredients in the regulation of JAK2/STAT3. |
• | the JAK2/STAT3 signaling pathway has dual roles in different cardiovascular diseases. |
Abbreviations : JAK2, STAT3, SH2, NTD, LD, TAD, IL-6, COL1A1, TIMP-1, MMP-1, SH2B1, Fn14, HSF1, TLR4, VEGF, M6A, IGF2BP, HUVECs, RBP4, Cyclin D1, Bcl-2,Bax, TNF-α, PAPP-A, G-CSF, EGFR, PPARγ, Caspase3, IL-23, α-SMA, IL-1β, IL-18, EF, HYSA, CTGF, ANP, BNP, β-MHC, VCAM-1, ICAM-1, COX-2, INOS, IL-10, NF-kB
Keywords : JAK2/STAT3, Cardiovascular Diseases, Natural Plants, Phytochemical Ingredients
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Vol 172
Article 116313- mars 2024 Retour au numéro
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