Relationship between blood culture time to positivity, mortality rate, and severity of bacteremia - 29/02/24
, S. Tokioka b, D. Kobayashi c, N. Mori aHighlights |
• | Time to positivity (TTP) > 24 h is associated with 30-day mortality for S. aureus. |
• | Other species did not show an association between TTP and mortality. |
• | Vasopressor use, old age, and TTP > 24 h are associated with higher 30-day mortality. |
Abstract |
Objectives |
We investigated the association between patient severity or mortality and time to positivity in bacteremia caused by various pathogens.
Patients and methods |
This single-center retrospective study included patients with positive blood culture results.
Results |
Longer time to positivity was associated with 30-day mortality for Staphylococcus aureus (221 cases, time to positivity: 17.4 h in the 30-day mortality group vs. 14.1 h in the survival group). Age, chronic kidney disease, cerebrovascular disease, hypertensive drug use, consciousness disorder, and minimal systolic blood pressure were significant predictors of 30-day mortality. For S. aureus, mortality within 30 days was significantly higher when time to positivity was > 24 h (p = 0.04). The time to positivity of Streptococcus pneumoniae, α, β-hemolytic Streptococcus, Enterococcus sp., Enterobacteriaceae, glucose-nonfermenting Gram-negative rods, Candida sp., and anaerobe was not significantly associated with 30-day mortality.
Conclusions |
Among various pathogens, time to positivity > 24 h was associated with 30-day mortality for S. aureus.
Le texte complet de cet article est disponible en PDF.Keywords : Bacteremia, Blood culture, Mortality, Staphylococcus aureus, Time to positivity
Abbreviations : TTP, HACEK, IQR, OR, CKD, MRSA
Plan
Vol 54 - N° 2
Article 104843- mars 2024 Retour au numéro
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