Diagnostic and therapeutic potentials of methyltransferase-like 3 in liver diseases - 29/02/24
Abstract |
Methyltransferase-like 3 (METTL3), a component of the RNA N6-methyladenosine (m6A) modification with a specific catalytic capacity, controls gene expression by actively regulating RNA splicing, nuclear export, stability, and translation, determines the fate of RNAs and assists in regulating biological processes. Studies conducted in recent decades have demonstrated the pivotal regulatory role of METTL3 in liver disorders, including hepatic lipid metabolism disorders, liver fibrosis, nonalcoholic steatohepatitis, and liver cancer. Although METTL3’s roles in these diseases have been extensively investigated, the regulatory network of METTL3 and its potential applications remain unexplored. In this review, we provide a comprehensive overview of the roles and mechanisms of METTL3 implicated in these diseases, establish a regulatory network of METTL3, evaluate the potential for targeting METTL3 for diagnosis and treatment, and discuss avenues for future development and research. We found relatively upregulated expressions of METTL3 in these liver diseases, demonstrating its potential as a diagnostic biomarker and therapeutic target.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | METTL3 regulates lipid metabolism in hepatic lipid metabolism disorder. |
• | METTL3 activates hepatic stellate cells into myofibroblasts in liver fibrosis. |
• | METTL3 promotes nonalcoholic fatty liver transit to nonalcoholic steatohepatitis. |
• | METTL3 facilitates the occurrence and progression of liver cancers. |
• | Targeting METTL3 for liver cancer treatment. |
Abbreviations : METTL3, m6A, LPS, METTL14, FTO, ALKBH5, YTHDF2, Pparα, Bmall, HSCs, ECM, ASICs, SPRY2, DGCR8, NASH, NAFL, CCL2, CDK9, HDAC1/2, 5'-UTR, TGF-b1, HCC, VIRMA, CBLL1, ZC3H13, OS, RFS, CNV, HB, CTNNB1, FEN1, IGF2BP2, Socs2, USP7, SPM, VM, EMT, Snail1, SUMO1, UBC9, miRNAs, H3K9me3, YTHDC1, HBV, HBx protein, HMGA2, HDGF, BTG2, AKT1, MMP, FOXO3
Keywords : Methyltransferase-like 3, Hepatic lipid metabolism disorder, Liver fibrosis, Nonalcoholic steatohepatitis, Liver cancer, Clinical potentials
Plan
Vol 172
Article 116157- mars 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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