Clinical features and outcomes in adults with COVID-19 during the pre-Omicron and Omicron waves - 29/02/24
, A. Schieber b, J.C. Ongagna b, A. Henric b, M. Eyriey b, M. Mohseni-Zadeh a, C. Ion a, K demesmay c, S. Gravier a, C. Kempf b
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Highlights |
• | The death rate for Omicron inpatients (n = 1142) was 11 % vs 16.9 % for pre-Omicron inpatients (n = 1690) |
• | Independent risk factors for death included unvaccinated status and comorbidities. |
• | Type of variant was not an independent risk factor for death. |
• | Omicron inpatients had fewer comorbidities but were more frequently immunosuppressed. |
• | Nosocomial COVID-19 was more frequent during Omicron waves (18.2% vs 15.4%) |
Abstract |
Objectives |
We conducted a single-center retrospective study to compare patient characteristics and death rates during the Omicron (O, December 01, 2021, to September 30, 2022) and pre-Omicron (PO, March 01, 1920, to October 31, 2021) periods.
Patients and Methods |
We retrospectively analyzed the data of 2932 patients (1242 (O) and 1690 (PO)) hospitalized (>24 h) with laboratory-confirmed COVID.
Results |
Compared to the PO period, O period patients were less frequently men, had a lower body mass index and fewer comorbidities except for immunosuppression and pregnancy. Nosocomial COVID-19 accounted for 18.2 % (O) and 15.4 % (PO) of cases (p = 0.05). Patient mortality rates during the O and PO periods were 11.0 % and 16.9 % (p < 0.001), respectively. Unvaccinated status (p < 0.001), existence of comorbidities, (p < 0.001) and high LDH value at baseline (p = 0.015), but not the period, were identified as factors likely to explain death.
Conclusion |
During the Omicron period, the inpatient death rate remained > 10 %, especially among unvaccinated and comorbid patients. Nosocomial cases were more frequent.
Le texte complet de cet article est disponible en PDF.Keywords : COVID-19, SARS-CoV-2 variants, Outcome, Mortality, Nosocomial cases
Plan
Vol 54 - N° 2
Article 104833- mars 2024 Retour au numéro
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