The efficacy of neoadjuvant chemotherapy is different for type 4 and large type 3 gastric cancer - 22/02/24
Abstract |
Background |
In the JCOG0501 study, neoadjuvant chemotherapy (NAC) failed to demonstrate survival benefits for type 4 and large type 3 gastric cancer (GC). The prognosis of these patients is still poor. We conducted this study to explore the value of NAC with non-SP regimens for type 4 and large type 3 GC in the Chinese population.
Methods |
We retrospectively collected data from our electronic medical record system. Patients with large type 3 or type 4 GC who underwent D2 gastrectomy and AC were included. Patients were divided into two groups based on whether they received NAC: the CSC (NAC + surgery + AC) and SC (surgery + AC) groups. The survival and perioperative outcomes for large type 3 or type 4 GC were analyzed between the CSC and SC groups, separately.
Results |
Between May 2009 and December 2018, 189 patients were reviewed. Among large type 3 GC, the 5-year overall survival (OS) rates for patients in the CSC and SC groups were 54.4 % and 28.0 %, respectively (P = 0.0008). Among type 4 GC, the 5-year OS rates for patients in the CSC and SC groups were 15.8 % and 24.8 %, respectively (P > 0.05).
Conclusions |
This study showed NAC can improve the prognosis of large type 3 GC. However, NAC did not demonstrate significant survival advantages for type 4 GC.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Large type 3 GC in the CSC group had better survival than those in the SC group. |
• | For large type 3 GC, neoadjuvant chemotherapy not only reduced surgical complications but also improved patient survival. |
• | There was no statistically significant difference in survival analysis for type 4 GC between the CSC and SC groups. |
Keywords : Gastric cancer, Borrmann, Type 4, Large type 3, Neoadjuvant chemotherapy
Plan
Vol 228
P. 273-278 - février 2024 Retour au numéro
Article précédent
- Survival following liver transplantation: A population-based nested case-control study
- Jake L. Cotton, Alejandro Suarez-Pierre, Jason J. Breithaupt, Dor Yoeli, Ioannis A. Ziogas, Rashikh A. Choudhury, Trevor L. Nydam, James J. Pomposelli, Elizabeth A. Pomfret, Megan A. Adams
- Prolonged travel time to transplantation center is associated with poor outcomes following heart transplantation
- Alejandro Suarez-Pierre, Jack Zakrzewski, Chiagoziem Anigbogu, John P. Iguidbashian, Ioannis A. Ziogas, Laura L. Peters, Amrut V. Ambardekar, Jordan RH. Hoffman, T Brett Reece, Joseph C. Cleveland, Jessica Y. Rove
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?