Hemoglobin Threshold for Blood Transfusion in Young Children Hospitalized with Iron Deficiency Anemia - 20/02/24

Doi : 10.1016/j.jpeds.2023.113878

Dou Lin Rose Sun, MD ¹, Allan Puran, MSc ², Mohammed Al Nuaimi, MD ^3,⁴, Layla AlRiyami, MD ³, Laura M. Kinlin, MD, MPH ^1,^2,⁵, Melanie Kirby-Allen, MD ^1,^5,⁶, Sanjay Mahant, MD, MSc ^1,^2,^5,^7,⁸, Peter J. Gill, MD, DPhil ^1,^2,^5,^7,⁸, Cornelia M. Borkhoff, PhD ^2,^7,^8,^{^{∗
Contributed equally as co-senior authors.}}, Patricia C. Parkin, MD ^1,^2,^5,^7,^8,^⁎^{^{∗
Contributed equally as co-senior authors.}}
¹ Faculty of Medicine, University of Toronto, Toronto, Canada
² Division of Pediatric Medicine and the Pediatric Outcomes Research Team, Hospital for Sick Children, Toronto, Canada
³ Division of Pediatric Hematology & Oncology, Tawam Hospital, Al-Ain, United Arab Emirates
⁴ Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates
⁵ Department of Pediatrics, University of Toronto, Toronto, Canada
⁶ Division of Pediatric Hematology Oncology, Hospital for Sick Children, Toronto, Canada
⁷ Child Health Evaluative Sciences, SickKids Research Institute, Hospital for Sick Children, Toronto, Canada
⁸ Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada

^∗Reprint requests: Patricia C. Parkin, MD, The Hospital for Sick Children, Toronto, ON, Canada.The Hospital for Sick ChildrenTorontoONCanada

Abstract

Current recommendations advise against blood transfusion in hemodynamically stable children with iron deficiency anemia. In an observational study of 125 children aged 6 through 36 months, hospitalized with iron deficiency anemia, we found that hemoglobin level predicted red blood cell transfusion (area under the curve 0.8862). A hemoglobin of 39 g/L had sensitivity 92% and specificity 72% for transfusion.

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Keywords : not in the title: hemoglobin, hemodynamic instability, inpatient care, transfusion complications, receiver operating curves, area under the curve, sensitivity, specificity

Abbreviations : AUC, ED, GPIU, ICU, ICD, IDA, PEWS, RBC, ROC

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Article 113878- mars 2024 Retour au numéro

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Hemoglobin Threshold for Blood Transfusion in Young Children Hospitalized with Iron Deficiency Anemia - 20/02/24

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