New concepts drive the development of delivery tools for sustainable treatment of diabetic complications - 04/02/24
Abstract |
Diabetic complications, especially diabetic retinopathy, diabetic nephropathy and painful diabetic neuropathy, account for a large portion of patients with diabetes and display rising global prevalence. They are the leading causes of blindness, kidney failure and hypersensitivity to pain caused by diabetes. Current approved therapeutics against the diabetic complications are few and exhibit limited efficacy. The enhanced cell-specificity, stability, biocompatibility, and loading capacity of drugs are essential for the mitigation of diabetic complications. In the article, we have critically discussed the recent studies over the past two years in material sciences and biochemistry. The insightful concepts in these studies drive the development of novel nanoparticles and mesenchymal stem cells-derived extracellular vesicles to meet the need for treatment of diabetic complications. Their underlying biochemical principles, advantages and limitations have been in-depth analyzed. The nanoparticles discussed in the article include double-headed nanodelivery system, nanozyme, ESC-HCM-B system, soft polymer nanostars, tetrahedral DNA nanostructures and hydrogels. They ameliorate the diabetic complication through attenuation of inflammation, apoptosis and restoration of metabolic homeostasis. Moreover, mesenchymal stem cell-derived extracellular vesicles efficiently deliver therapeutic proteins to the retinal cells to suppress the angiogenesis, inflammation, apoptosis and oxidative stress to reverse diabetic retinopathy. Collectively, we provide a critical discussion on the concept, mechanism and therapeutic applicability of new delivery tools to treat these three devastating diabetic complications.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Double-headed nanoparticles increase the uptake and loading capacity of drugs. |
• | ESC-HCM-B system enhances the specificity, stability and biocompatibility of drugs. |
• | MSC-EVs deliver therapeutic proteins to the retina to suppress diabetic retinopathy. |
Abbreviation : AMPK, BDNF, DKD, DN, DRG, DR, ESC-HCM-B, GCL, GLP-1, GPCR, hPSC, hUCMSC, LNP, MC-1R, MiRNA, MSC, MSC-EV, NEDD4, NK-1, NLRP3, Nrf2, PDN, PKC, PLGA, PTEN, RPE, SC, sEV, SGLT2, STZ, TRP, TRPA1, TRPC, TRPV1, VEGF, VEGFA, XOR
Keywords : Diabetic retinopathy, Diabetic nephropathy, Painful diabetic neuropathy, Delivery tool, Nanoparticle, Extracellular vesicles
Plan
Vol 171
Article 116206- février 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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