Anticancer effects of solasonine: Evidence and possible mechanisms - 04/02/24
, HuaXin Wang a, ⁎ Abstract |
The effectiveness and safety of traditional Chinese medicine's active ingredients in anti-tumor effects have attracted widespread attention worldwide. Solasonine is the main anti-tumor component of the traditional Chinese medicine Solanum nigrum L, which can inhibit tumor cell proliferation, induce apoptosis, induce ferroptosis in tumor cells, and inhibit of tumor cell metastasis, thereby inhibiting tumor progression. Therefore, we summarized anti-tumor mechanisms and targets of solasonine to provide new ideas and theoretical basis for its further development and application.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Solasonine is the main anti-tumor component of the traditional Chinese medicine Solanum nigrum. |
• | Solasonine exerts an anti-tumor role in a variety of tumors. |
• | Solasonine has a variety of anti-tumor molecular mechanisms. |
Abbreviations : SS, mTOR, p70S6K, CCAT1, SP1, AMPK, CDK, IRF-5, MAPK, ERK, NRP1, Bcl-2, Bax, Bcl-xL, cyt-c, PARP, NF-κB, PI3K, AKT, GSH, GPX4, GSS, ROS, EMT, OS, MMPs, EMMPRIN, RECK, TIMPs
Keywords : Solasonine, Tumor, Antitumor activity, Pharmacological mechanism
Plan
Vol 171
Article 116146- février 2024 Retour au numéro
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