The role and therapeutic potential of nuclear factor κB (NF-κB) in ischemic stroke - 04/02/24
Abstract |
Stroke is a prevalent cerebrovascular condition with a global impact, causing significant rates of illness and death. Despite extensive research, the available treatment options for stroke remain restricted. Hence, it is crucial to gain a deeper understanding of the molecular mechanisms associated with the onset and advancement of stroke in order to establish a theoretical foundation for novel preventive and therapeutic approaches. NF-κB, also known as nuclear factor κB, is a transcription factor responsible for controlling the expression of numerous genes and plays a crucial role in diverse physiological processes. NF-κB is triggered and regulates neuroinflammation and other processes after stroke, promoting the generation of cytokine storms and contributing to the advancement of ischemic stroke (IS). Therefore, NF-κB could potentially play a vital role in stroke by regulating diverse pathophysiological processes. This review provides an overview of the functions of NF-κB in stroke and its governing mechanisms. In addition, our attention is directed towards various potential therapies that aim to inhibit the NF-κB signaling pathway in order to offer valuable insights for the advancement of innovative treatment approaches for stroke.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
● | NF-κB plays a key role in neuroinflammation following ischemic stroke. |
● | NF-κB is involved in regulating the pathological mechanisms of ischemic stroke. |
● | A series of therapies exert neuroprotective effects on ischemic stroke via inhibiting NF-κB signalling pathway. |
Abbreviations : BBB, CI/R, CNS, DALYs, DAMPs, EA, ECs, EPO, FOXO3a, GBE, GDL, GK, GKA, GKB, ICAM-1, IKK, IL-1, I/R, IS, JNK, LPS, LTβ, MCAO, MMP9, mTOR, NF-κB, NIK, NLRP3, Nrf2, OGD, OTULIN, PAMPs, P-EPO, PRMT5, ROS, S1P, SIRT1, Sphks, STAT3, TLRs, TK, TNF, tPA, TRAF1/2, VCAM-1, VEGF
Keywords : Nuclear factor κB, Ischemic stroke, Neuroinflammation, Blood-brain-barrier
Plan
Vol 171
Article 116140- février 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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