Persistence of post-COVID symptoms in the general population two years after SARS-CoV-2 infection: A systematic review and meta-analysis - 03/02/24
, Kin Israel Notarte b, Raymart Macasaet c, Jacqueline Veronica Velasco d, Jesus Alfonso Catahay e, Abbygail Therese Ver d, William Chung b, Juan A. Valera-Calero f, Marcos Navarro-Santana f
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Summary |
Objective |
This meta-analysis investigated the prevalence of post-COVID symptoms two-years after SARS-CoV-2 infection.
Methods |
Electronic literature searches on PubMed, MEDLINE, CINAHL, EMBASE, Web of Science databases, and on medRxiv/bioRxiv preprint servers were conducted up to October 1, 2023. Studies reporting data on post-COVID symptoms at two-years after infection were included. Methodological quality was assessed using the Newcastle-Ottawa Scale. Random-effects models were used for meta-analytical pooled prevalence of each symptom.
Results |
From 742 studies identified, twelve met inclusion criteria. The sample included 7912 COVID-19 survivors (50.7% female; age: 59.5, SD: 16.3). Post-COVID symptoms were assessed at a follow-up of 722.9 (SD: 51.5) days after. The overall methodological quality of studies was moderate (mean: 6/10, SD: 1.2 points). The most prevalent post-COVID symptoms two-years after SARS-CoV-2 infection were fatigue (28.0%, 95%CI 12.0–47.0), cognitive impairments (27.6%, 95%CI 12.6–45.8), and pain (8.4%, 95%CI 4.9–12.8). Psychological disturbances such as anxiety (13.4%, 95%CI 6.3–22.5) and depressive (18.0%, 95%CI 4.8–36.7) levels as well as sleep problems (20.9%, 95%CI 5.25–43.25) were also prevalent. Pooled data showed high heterogeneity (I2 ≥ 75%).
Conclusion |
This meta-analysis shows the presence of post-COVID symptoms in 30% of patients two-years after COVID-19. Fatigue, cognitive disorders, and pain were the most prevalent post-COVID symptoms. Psychological disturbances as well as sleep problems were still present two-years after COVID-19.
Le texte complet de cet article est disponible en PDF.Highlights |
• | The prevalence of post-COVID symptoms is 30% two-years after COVID-19. |
• | Fatigue, cognitive disorders, and pain are the most prevalent post-COVID symptoms two-years after. |
• | The prevalence of anxiety, depression and sleep problems reaches 20% two-years after COVID-19. |
Keywords : Post-COVID, Symptoms, Fatigue, Meta-analysis, Prevalence, Years
Plan
Vol 88 - N° 2
P. 77-88 - février 2024 Retour au numéro
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