Virus-containing migrasomes enable poxviruses to evade tecovirimat/ST-246 treatment - 03/02/24
Doi : 10.1016/j.jinf.2023.12.005
Wenbo Zhao a, b, c, Xichi Tang a, b, c, Leiliang Zhang a, b, c, ⁎ 
a Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China
b Department of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
c Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⁎Corresponding author at: Department of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.Department of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical SciencesJinanShandongChina
Highlights |
• | Tecovirimat/ST-246 did not block migrasomes formation induced by VACV. |
• | Migrasomes contain VACV virons in the presence of tecovirimat. |
• | Poxvirus could be transmitted through migrasomes in the presence of tecovirimat. |
• | Tecovirimat treatment could not completely stop mpox. |
© 2023
The British Infection Association. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 88 - N° 2
P. 203-205 - février 2024 Retour au numéro
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