Mortality Associated With Proportionality of Secondary Mitral Regurgitation After Transcatheter Mitral Valve Repair: North American Mitraclip for Functional Mitral Regurgitation Registry - 30/01/24
, Milo Engoren, MD a, Scott M. Chadderdon, MD b, Evelio Rodriguez, MD c, M. Andrew Morse, MD d, Mani A. Vannan, MD e, Pradeep K. Yadav, MD e, Michael Morcos, MD f, Flora Li, MD g, Mark Reisman, MD h, Enrique Garcia-Sayan, MD i, Deepa Raghunathan, MD i, Nishtha Sodhi, MD j, Paul Sorajja, MD k, Lily Chen, MD l, Jason H. Rogers, MD l, Marcella A. Calfon, Press, MD, PhD m, Christopher P. Kovach, MD n, Edward A. Gill, MD n, Firas E. Zahr, MD b, Stanley J. Chetcuti, MD o, Yuan Yuan, MS a, Graciela B. Mentz, PhD a, D. Scott Lim, MD j, Gorav Ailawadi, MD pRésumé |
The association, if any, between the effective regurgitant orifice area (EROA) to left ventricular end-diastolic volume (LVEDV) ratio and 1-year mortality is controversial in patients who undergo mitral transcatheter edge-to-edge repair (m-TEER) with the MitraClip system (Abbott Vascular, Santa Clara, CA). This study's objective was to determine the association between EROA/LVEDV and 1-year mortality in patients who undergo m-TEER with MitraClip. In patients with severe secondary (functional) mitral regurgitation (MR), we analyzed registry data from 11 centers using generalized linear models with the generalized estimating equations approach. We studied 525 patients with secondary MR who underwent m-TEER. Most patients were male (63%) and were New York Heart Association class III (61%) or IV (21%). Mitral regurgitation was caused by ischemic cardiomyopathy in 51% of patients. EROA/LVEDV values varied widely, with median = 0.19 mm2/ml, interquartile range [0.12,0.28] mm2/ml, and 187 patients (36%) had values <0.15 mm2/ml. Postprocedural mitral regurgitation severity was substantially alleviated, being 1+ or less in 74%, 2+ in 20%, 3+ in 4%, and 4+ in 2%; 1-year mortality was 22%. After adjustment for confounders, the logarithmic transformation (Ln) of EROA/LVEDV was associated with 1-year mortality (odds ratio 0.600, 95% confidence interval 0.386 to 0.933, p = 0.023). A higher Society of Thoracic Surgeons risk score was also associated with increased mortality. In conclusion, lower values of Ln(EROA/LVEDV) were associated with increased 1-year mortality in this multicenter registry. The slope of the association is steep at low values but gradually flattens as Ln(EROA/LVEDV) increases.
Le texte complet de cet article est disponible en PDF.Keywords : proportionality, functional mitral regurgitation, regurgitant orifice, mitral transcatheter edge-to-edge repair
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Vol 213
P. 99-105 - février 2024 Retour au numéro
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