Effect of using hypotension prediction index versus conventional goal-directed haemodynamic management to reduce intraoperative hypotension in non-cardiac surgery: A randomised controlled trial - 11/01/24
, Makishi Maeda, MD, Tatsuya Kunigo, MD, Tomoe Sato, MD, Kanako Takahashi, MD, Sho Ohno, MD, Tomoki Hirahata, MD, Michiaki Yamakage, MD, PhDAbstract |
Study objective |
It remains unclear whether it is the hypotension prediction index itself or goal-directed haemodynamic therapy that mitigates intraoperative hypotension.
Design |
A single centre randomised controlled trial.
Setting |
Sapporo Medical University Hospital.
Patients |
A total of 64 adults patients undergoing major non-cardiac surgery under general anaesthesia.
Interventions |
Patients were randomly assigned to either group receiving conventional goal-directed therapy (FloTrac group) or combination of the hypotension prediction index and conventional goal-directed therapy (HPI group). To investigate the independent utility of the index, the peak rates of arterial pressure and dynamic arterial elastance were not included in the treatment algorithm for the HPI group.
Measurements |
The primary outcome was the time-weighted average of the areas under the threshold. Secondary outcomes were area under the threshold, the number of hypotension events, total duration of hypotension events, mean mean arterial pressure during the hypotension period, number of hypotension events with mean arterial pressure < 50 mmHg, amounts of fluids, blood products, blood loss, and urine output, frequency and amount of vasoactive agents, concentration of haemoglobin during the monitoring period, and 30-day mortality.
Main results |
The time-weighted average of the area below the threshold was lower in the HPI group than in the control group; 0.19 mmHg (interquartile range, 0.06–0.80 mmHg) vs. 0.66 mmHg (0.28–1.67 mmHg), with a median difference of −0.41 mmHg (95% confidence interval, −0.69 to −0.10 mmHg), p = 0.005. Norepinephrine was administered to 12 (40%) and 5 (17%) patients in the HPI and FloTrac groups, respectively (p = 0.045). No significant differences were observed in the volumes of fluid and blood products between the study groups.
Conclusions |
The current randomised controlled trial results suggest that using the hypotension prediction index independently lowered the cumulative amount of intraoperative hypotension during major non-cardiac surgery.
Le texte complet de cet article est disponible en PDF.Graphical abstract |
Highlights |
• | It remains unclear whether it is HPI itself or goal-directed haemodynamic therapy that mitigates intraoperative hypotension. |
• | The independent utility of HPI was evaluated during major non-cardiac surgery. |
• | Using HPI independently lowered the cumulative amount of intraoperative hypotension during major non-cardiac surgery. |
• | HPI monitoring facilitated prompt use of vasopressors to reduce intraoperative hypotension. |
Keywords : Hypotension prediction index, Intraoperative hypotension, Myocardial injury, Acute kidney injury, Noncardiac surgery
Plan
Vol 93
Article 111348- mai 2024 Retour au numéro
Article précédent
- Post-operative urinary retention is impacted by neuromuscular block reversal agent choice: A retrospective cohort study in US hospital setting
- Lori D. Bash, Vladimir Turzhitsky, Robert J. Mark, Ira S. Hofer, Toby N. Weingarten
- Effects of intraoperative sodium oxybate infusion on post-operative sleep quality in patients undergoing gynecological laparoscopic surgery: A randomized clinical trial
- Meiying Cui, Tianyi Xing, Anqi Zhao, Lanlan Zheng, Xinping Zhang, Hang Xue, Ziyi Wu, Fang Wang, Ping Zhao
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?