Resistance Exercise Program in Cognitively Normal Older Adults: CERT-Based Exercise Protocol of the AGUEDA Randomized Controlled Trial - 11/01/24

Doi : 10.1007/s12603-023-1982-1 
Beatriz Fernandez-Gamez 1 , P. Solis-Urra 1, 2, 3, M. Olvera-Rojas 1, C. Molina-Hidalgo 1, 4, 5, J. Fernández-Ortega 1, C.P. Lara 1, A. Coca-Pulido 1, D. Bellón 1, A. Sclafani 1, J. Mora-Gonzalez 1, A. Toval 1, I. Martín-Fuentes 1, E.A. Bakker 1, R.M. Lozano 6, S. Navarrete 6, D. Jiménez-Pavón 7, 8, T. Liu-Ambrose 9, 10, 11, K.I. Erickson 4, 5, F.B. Ortega 1, 12, 13, Irene Esteban-Cornejo 1, 12, 14
1 Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Carretera de Alfacar, 21, 18071, Granada, Spain 
2 Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, 18014, Granada, Spain 
3 Faculty of Education and Social Sciences, Universidad Andres Bello, 2531015, Viña del Mar, Chile 
4 Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA 
5 Neuroscience Institute, AdventHealth Research Institute, Orlando, Florida, USA 
6 Junta de Andalucía, Andalusian Centre of Sport Medicine (CAMD), Granada, Spain 
7 MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences and Biomedical Research Innovation Institute of Cádiz, University of Cadiz, Andalusia, Spain 
8 CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain 
9 Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada 
10 Centre for Aging SMART at Vancouver Coastal Health, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada 
11 Djavad Mowafaghian Centre for Brain Health, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada 
12 Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain 
13 Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland 
14 Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain 

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Abstract

Objectives

To provide a comprehensive CERT (Consensus on Exercise Reporting Template)-based description of the resistance exercise program implemented in the AGUEDA (Active Gains in brain Using Exercise During Aging) study, a randomized controlled trial investigating the effects of a 24-week supervised resistance exercise program on executive function and related brain structure and function in cognitively normal older adults.

Design and Participants

90 cognitively normal older adults aged 65 to 80 were randomized (1:1) to a: 1) resistance exercise group; or a 2) wait-list control group. Participants in the exercise group (n = 46) performed 180 min/week of resistance exercise (3 supervised sessions per week, 60 min/session) for 24 weeks.

Intervention

The exercise program consisted of a combination of upper and lower limb exercises using elastic bands and the participant's own body weight as the main resistance. The load and intensity were based on the resistance of the elastic bands (7 resistances), number of repetitions (individualized), motor complexity of exercises (3 levels), sets and rest (3 sets/60 sec rest), execution time (40–60 sec) and velocity (as fast as possible).

Settings

The maximum prescribed-target intensity was 70–80% of the participants' maximum rate of perceived exertion (7–8 RPE). Heart rate, sleep quality and feeling scale were recorded during all exercise sessions. Those in the wait-list control group (n = 44) were asked to maintain their usual lifestyle. The feasibility of AGUEDA project was evaluated by retention, adherence, adverse events and cost estimation on the exercise program.

Results and Conclusions

This study details the exercise program of the AGUEDA trial, including well-described multi-language manuals and videos, which can be used by public health professionals, or general public who wish to implement a feasible and low-cost resistance exercise program. The AGUEDA exercise program seems to be feasible by the high retention (95.6%) and attendance rate (85.7%), very low serious adverse event (1%) and low economic cost (144.23 € /participant/24 weeks). We predict that a 24-week resistance exercise program will have positive effects on brain health in cognitively normal older adults.

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Key words : Aging, brain health, cognition, physical activity, strength training


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Vol 27 - N° 10

P. 885-893 - septembre 2023 Retour au numéro
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