Effect of metabolic reprogramming on the immune microenvironment in gastric cancer - 05/01/24
, Xuemei Liu a, ⁎ Abstract |
Gastric cancer (GC) is a malignant tumor of the gastrointestinal tract with a high mortality rate worldwide, a low early detection rate and a poor prognosis. The rise of metabolomics has facilitated the early detection and treatment of GC. Metabolism in the GC tumor microenvironment (TME) mainly includes glucose metabolism, lipid metabolism and amino acid metabolism, which provide energy and nutrients for GC cell proliferation and migration. Abnormal tumor metabolism can influence tumor progression by regulating the functions of immune cells and immune molecules in the TME, thereby contributing to tumor immune escape. Thus, in this review, we summarize the impact of metabolism on the TME during GC progression. We also propose novel strategies to modulate antitumor immune responses by targeting metabolism.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | We summarized the exact roles of the three major metabolisms in gastric cancer and their molecular mechanisms. |
• | We summarized the interaction between metabolism and the tumour immune microenvironment in gastric cancer. |
• | We summarized the strategies for targeting gastric cancer based on metabolic modulation of immunity. |
Abbreviations : AHR, ATP, APOC2, Arg, ASCT2, AMPK, CAFs, CPT1A, CACT, CTL, CCL2, COL12A1, CTLA-4, DCs, EBVaGC, EC, EMT, ECM, FBP, FAO, FA, FABP4, FABP5, GC, GLUT1, GLUT3, Gln, GLS, Glu, HK2, HIF-1α, HPD, HMG-CoA, HMGCR, Hp, IFN-γ, ICIs, ICB, ICAM-1, IDO1, iNOS, Kyn, KP, LDHA, LA, LDHB, LCFAs, LXR, mTOR, mAbs, MCT-1, MCT-4, MMP, MVA, MDSCs, M1, M2, NF-κB, NKG2D, NK, NOS, OXPHOS, ox-LDL, PKM2, PPAR-α, PD-1, PD-L1, ROS, TME, TILs, TAMs, TILs, TNF-α, TCR, TIGIT, TIME, Trp, TGM2, Tregs, Teff, VEGF, 25-HC
Keywords : Metabolism, Immune microenvironment, Gastric cancer, Cancer immunity, TIME
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Vol 170
Article 116030- janvier 2024 Retour au numéro
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