Comparing Gastrointestinal Endoscopy Findings in Children with Autism, Developmental Delay, or Typical Development - 11/12/23
, Saige Greenwell, DO 1, Enju Liu, PhD, MD 2, Timothy Buie, MD 1, Jocelyn Silvester, MD, PhD 1, McKenzie Leier, BA, MPA 1, Maura Filippelli, BS, RN, BSN 1, Athos Bousvaros, MD 1, Bridget Hron, MD, MMSc 1Abstract |
Objective |
To compare endoscopic and histologic upper endoscopy (esophagogastroduodenoscopy [EGD]) findings in children with autism spectrum disorders (ASD) to age- and gender-matched controls with developmental delay (DD) or with typical development (TD).
Methods |
Retrospective, cross-sectional study of children undergoing EGD, identifying those diagnosed with ASD, and matching on age and gender to children with DD or TD in ratio of 1:1:2. Rates of EGD findings were compared between the 3 groups using χ² or Fisher exact test. Multivariable linear regression was performed to identify predictors of abnormal histology.
Results |
A total of 2104 patients were included (526 ASD; 526 DD; 1052 TD). Children with ASD had higher rates of abnormal esophageal histology (ASD 38.4%; DD 33.4%; TD 30.4%, P = .008), particularly esophagitis. In multivariable modeling, ASD diagnosis was an independent predictor of abnormal esophageal histology (OR [95% CI] 1.38 [1.09, 1.76]) compared with TD. Stomach findings did not differ among the groups. In the duodenum, histologic abnormalities were observed with lower frequency in ASD (ASD 17.0%; DD 20.1%; TD 24.2%, P = .005). In multivariable analysis, ASD diagnosis was not a significant predictor (OR 0.78 [0.56, 1.09]) of abnormal duodenal histology.
Conclusions |
Children with ASD have higher rates of histologic esophagitis compared with age- and gender-matched DD and TD controls. ASD was a significant independent predictor of abnormal esophageal, but not, duodenal, histology. These results underscore the importance of EGD in children with ASD.
Le texte complet de cet article est disponible en PDF.Abbreviations : ASD, BCH, DD, EGD, ICD, PPI, TD
Plan
Vol 264
Article 113737- janvier 2024 Retour au numéro
Article précédent
- Early Elbow Flexion Contracture Predicts Shoulder Contracture in Infants with Brachial Plexus Birth Injury
- David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
- The Irritable Infant in the Neonatal Intensive Care Unit: Risk Factors and Biomarkers of Gastroesophageal Reflux Disease
- Minna Njeh, Roseanna Helmick, Enas Alshaikh, Kailyn Marcano, Alexis Alexander, Erika Osborn, Sudarshan R. Jadcherla
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?