Blood Pressure Outcomes in NICU-Admitted Infants with Neonatal Hypertension: A Pediatric Nephrology Research Consortium Study - 11/12/23
Abstract |
Objective |
To describe the blood pressure outcomes of infants admitted to the neonatal intensive care unit (NICU) with idiopathic (nonsecondary) hypertension (HTN) who were discharged on antihypertensive therapy.
Study design |
Retrospective, multicenter study of 14 centers within the Pediatric Nephrology Research Consortium. We included all infants with a diagnosis of idiopathic HTN discharged from the NICU on antihypertensive treatment. The primary outcome was time to discontinuation of antihypertensive therapy, grouped into (≤6 months, >6 months to 1 year, and >1 year). Comparisons between groups were made with χ2 tests, Fisher's exact tests, and ANOVA.
Results |
Data from 118 infants (66% male) were included. Calcium channel blockers were the most prescribed class of antihypertensives (56%) in the cohort. The percentages remaining on antihypertensives after NICU discharge were 60% at 6 months, 26% at 1 year, and 7% at 2 years. Antenatal steroid treatment was associated with decreased likelihood of antihypertensive therapy >1 year after discharge.
Conclusions |
This multicenter study reports that most infants admitted to the NICU diagnosed with idiopathic HTN will discontinue antihypertensive treatment by 2 years after NICU discharge. These data provide important insights into the outcome of neonatal HTN, but should be confirmed prospectively.
Le texte complet de cet article est disponible en PDF.Keywords : hypertension, pediatric, neonates, NICU
Abbreviations : ACE, HTN, NICU
Plan
N.X. and M.S. contributed equally. |
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Portions of this data were presented as a platform presentation at Pediatric Academic Society Meeting, April 24-May 19, 2019, Baltimore, MD. |
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Deidentified individual participant data will be made available to researchers who provide a methodologically sound proposal for use in achieving the goals of the approved proposal. |
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Article 113765- janvier 2024 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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