Complement-pentraxins synergy: Navigating the immune battlefield and beyond - 04/12/23
, Raffaella Parente b, Hang Zhong c, d, Yi Sun a, Cecilia Garlanda b, c, Andrea Doni b, ⁎ Abstract |
The complement is a crucial immune defense system that triggers rapid immune responses and offers efficient protection against foreign invaders and unwanted host elements, acting as a sentinel. Activation of the complement system occurs upon the recognition of pathogenic microorganisms or altered self-cells by pattern-recognition molecules (PRMs) such as C1q, collectins, ficolins, and pentraxins. Recent accumulating evidence shows that pentraxins establish a cooperative network with different classes of effector PRMs, resulting in synergistic effects in complement activation. This review describes the complex interaction of pentraxins with the complement system and the implications of this cooperative network for effective host defense during pathogen invasion.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Humoral innate immune cooperation triggers cross-activation of diverse defense pathways. |
• | Soluble pattern recognition molecules (PRMs) interact with complement components, amplifying immune functions. |
• | Soluble PRMs regulate complement activation, mitigating inflammation-mediated tissue damage. |
Abbreviations : 1, A. fumigatus, AP, B. cepacian, BAL, BGRPs, BrM, C. albicans, C10M, CASP3, CHIKV, CL-10, CL-11, CL-12, CL-LK, CP, CR1, CR3, CR4, CRP, DAMPs, E. coli, fB, FBG, fD, fH, fI, fP, K. pneumoniae, LP, MAC, MASP, MBL, MCP, mCRP, N. meningitidis, P. aeruginosa, PAMPs, pCRP*, pCRP, PGRPs, PRMs, proPO, PTX3, RRV, S. enterica, S. pneumoniae, S. pyogenes
Keywords : Pentraxins, Collectins, Ficolins, Complement activation, Immune response, Pathogenic infection and inflammation
Plan
Vol 169
Article 115878- décembre 2023 Retour au numéro
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