Biological role of long non-coding RNA KCNQ1OT1 in cancer progression - 04/12/23
Abstract |
Long non-coding RNAs (lncRNAs) are a type of RNAs that are more than 200 nucleotides without protein-coding potential. In recent years, more and more attention has been paid to the role of lncRNAs in cancer pathogenesis. LncRNA KCNQ1 overlapping transcript 1 (KCNQ1OT1) is located on chromosome 11p15.5 with a total length of 91 kb and is highly expressed in various malignancies, which is closely related to tumor growth, lymph node metastasis, survival cycle and recurrence rate. In addition, KCNQ1OT1 is involved in the regulation of PI3K/AKT and Wnt/β-catenin signaling pathways. In this review, the mechanism and related progress of KCNQ1OT1 in different cancers were reviewed. It was found that KCNQ1OT1 can stabilize mRNA expression through sponging miRNA, which not only induced tumor cell proliferation, migration, invasion, drug resistance, epithelial-mesenchymal transition (EMT) and inhibited cell apoptosis in vitro, but also promoted tumor growth and metastasis in vivo. Therefore, as a new biomarker and therapeutic target, KCNQ1OT1 has broad prospects for the diagnosis and treatment of different cancers.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | The expression of KCNQ1OT1 is abnormal in different cancers. |
• | KCNQ1OT1 involves regulatory networks and signaling pathways. |
• | KCNQ1OT1 is a promising marker for tumor diagnosis, treatment and prognosis. |
Abbreviations : lncRNAs, KCNQ1OT1, EMT, NCRs, miRNAs, tRNAs, rRNAs, CRC, OC, HCC, BC, BRCA, EC, OSCC, ceRNAs, CISH, IBC, CANP10, NA, CCNE2, EIF2B5, GC, qRT-PCR, HS3ST3B1, TSCC, TRIM14, TC, IARC, HYOU1, LOXL2, CC, RB, HIF-α, NSCLC, LUAD, TPX-2, RNF2, SBRT, ATG-5, SCLC, STAT3, HK2, ATG4B, READ, COAD, NPC, PA, CCA, NB, MSSCC, ESCC, LSCC, ACC, BLCA, CESC, CHOL, DLBC, ESCA, GBM, HNSC, KICH, KIRC, KIRP, LAML, LGG, LIHC, LUSC, MESO, PAAD, PCPG, PRAD, SARC, SKCM, STAD, TGCT, THCA, THYM, UCEC, UCS, UVM
Keywords : Long noncoding RNA, KCNQ1OT1, Cancer, Signaling pathway, Progression
Plan
Vol 169
Article 115876- décembre 2023 Retour au numéro
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