Impact of ovarian diseases on fertility reserve as assessed through serum AMH levels in reproductive age women - 30/11/23
, Shubhangi Srivastava a , Nidhi Singh b, ⁎ , Wahid Ali c
Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.
Connectez-vous pour en bénéficier!
Highlights |
• | This paper has compared Serum AMH between benign ovarian diseases, endmetriomas and ovarian malignancy to assess their effect on fertility reserve. |
• | S. AMH levels were found to be significantly lower in malignant ovarian tumours. |
• | Compared to benign ovarian diseases S. AMH levels were significantly lower in endometriosis indicating adverse effect of endometriosis on ovarian reserve. |
• | There was an inverse and statistically significant correlation in mean S. AMH levels with CA-125 levels as well (p = 0.042). |
Abstract |
Aims and objectives |
The aim of this study was to assess the effect of ovarian diseases on fertility reserve evaluating serum Anti-Mullerian Hormone (AMH) levels.
Materials and methods |
This was a prospective study conducted on 66 reproductive age patients operated for an ovarian mass in the Department of Obstetrics and Gynaecology of a tertiary care teaching hospital in North India. The study included n = 18 cases of ovarian cancer, n = 20 cases of endometrioma and n = 28 cases of other benign ovarian disease. 5 ml of venous blood sample was obtained prior to surgical intervention for serum AMH analysis. Fertility sparing surgeries were done in n = 48 cases and n = 18 cases underwent radical surgeries. Histopathology (HPE) reports were recorded for all cases post-surgery. Serum AMH was correlated with HPE report to see the effect of various ovarian diseases on fertility status.
Result |
Serum AMH levels in malignant (0.34 ± 0.44 ng/mL) and endometrioma cases (1.50 ± 0.62 ng/mL) were significantly lower (p < 0.05) as compared to those found in cases affected by other inflammatory/benign cyst (3.93 ± 4.76 ng/mL). Ovarian cancer cases had the lowest serum AMH value (0.34 ± 0.44 ng/mL), well below the normal range.
Conclusion |
Ovarian cancer has an important adverse effect on ovarian fertility reserve, greater than endometriomas. Other benign ovarian tumors do not affect fertility reserve.
Le texte complet de cet article est disponible en PDF.Keywords : Anti-müllerian hormone, Benign ovarian tumor, Endometrioma, Laparoscopic cystectomy, Malignant ovarian tumor, Ovarian reserve
Plan
Vol 4
Article 100051- décembre 2023 Retour au numéro
Article précédent
- Correlation of new menstrual symptom abnormalities (FIGO 2018) with endometrial histopathology in cases of abnormal uterine bleeding
- Nisha Singh, Shefali Aggarwal, Riddhi Jaiswal
- Pregnancy following ablation therapy: a literature review
- Anna Heylen, Jasper Verguts, Lieselore Vandermeulen, Thierry Van den Bosch
Bienvenue sur EM-consulte, la référence des professionnels de santé.