Clostridial prosthetic joint infections: A series of 16 cases and literature review - 15/11/23
the CRIOGO (Centre de Référence des Infections Ostéo-articulaires du Grand Ouest) Study Team
Highlights |
• | C. perfringens was the most frequently involved species in this series of clostridial PJIs. |
• | Patients experiencing clostridial PJI were elderly at the time of arthroplasty and PJI. |
• | Most of the PJIs in this series were early- or delayed-onset infections. |
• | The prognosis for clostridial PJIs remains poor. |
• | DAIR with a 12-week antimicrobial therapy may be a suitable strategy. |
Abstract |
Objectives |
Prosthetic joint infections (PJIs) due to the Clostridium species have not been widely investigated. We aimed to characterize these uncommon infections.
Methods |
We conducted a retrospective study between 2003 and 2020 in six French hospitals combined with a review of the literature.
Results |
The main conclusions obtained from the 16 patients included were reinforced by the literature analysis: (i) Clostridium perfringens was the most frequently involved species, (ii) patients presented an advanced age at the time of prosthesis placement and infection, (iii) most of the infections were early- or delayed-onset, (iv) the prognosis for these PJIs remains poor, (v) when performed (n = 5), DAIR with 12-week antimicrobial therapy led to a favorable outcome in 80% of cases.
Conclusions |
Given the low incidence of this infection, our work represents the largest series of clostridial PJIs reported to date and highlights some specificities of these infections. Further prospective studies are needed to confirm these results.
Le texte complet de cet article est disponible en PDF.Keywords : Case series, Clostridium perfringens, Literature review, Prosthetic joint infections
Abbreviations : BMI, CKD, DAIR, IQR, MD, NA, PJI, THA, TKA
Plan
Vol 53 - N° 8
Article 104776- octobre 2023 Retour au numéro
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